Document Detail

Role of diet and fuel overabundance in the development and progression of heart failure.
MedLine Citation:
PMID:  18343896     Owner:  NLM     Status:  MEDLINE    
Under physiological conditions, the human heart derives energy from glucose, fatty acids, and/or lactate depending upon substrate availability, circulating hormone levels, and nutritional status. Circulating free fatty acid and glucose levels often exceed the normal range, as observed with type 2 diabetes, obesity, or physical inactivity. Chronic exposure of the heart to high plasma levels of free fatty acids may cause accumulation of toxic lipid intermediates within cardiomyocytes. Furthermore, suppression of glucose oxidation by increased fatty acid uptake shunts glucose into the oxidative pentose phosphate and hexosamine biosynthetic pathways, both of which yield potentially harmful products. Noxious derivatives of aberrant glucose and fatty acid oxidation can activate signalling cascades leading to myocyte dysfunction or death, processes termed 'glucotoxicity' and 'lipotoxicity'. This review discusses the effects of dietary extremes (e.g. high fat and high carbohydrate consumption) and substrate overabundance in the context of heart failure (HF) development and progression. Emerging data suggest that substrate excess leads to cardiac dysfunction and HF, which may be prevented or slowed by maintaining low body fat and high insulin sensitivity and consuming a diet of low glycaemic load that is high in mono- and polyunsaturated fatty acids.
David J Chess; William C Stanley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2008-03-14
Journal Detail:
Title:  Cardiovascular research     Volume:  79     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-02     Completed Date:  2008-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  269-78     Citation Subset:  IM    
Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
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MeSH Terms
Dietary Carbohydrates / adverse effects
Dietary Fats / adverse effects
Disease Progression
Eating / physiology*
Heart Failure / etiology,  physiopathology*
Grant Support
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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