Document Detail


Role of cytokines in the regulation of reproductive function.
MedLine Citation:
PMID:  18019018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The levels of 17 cytokines in the follicular fluid were measured by multiplex proteome analysis at the peak of stimulated ovulation during the in vitro fertilization cycle. In patients with ineffective folliculogenesis, the concentrations of IL-2, IL-4, IL-7, and granulocytic CSF in the follicular fluid were significantly lower than in women with greater mean number of collected oocytes. It was shown that multicomponent cytokine deficit was associated with lower production of high quality oocytes and lower efficiency of fertilization of the resultant oocytes in vitro. The absence of pregnancy after in vitro fertilization cycle is associated with lower levels of IL-2, IL-4, IL-7, granulocytic CSF, and macrophagic inflammatory protein 1b in combination with elevated contents of IL-8 and IL-13. The results attest to an important role of cytokines in the regulation of oogenesis and in preparation of the endometrium to implantation of the embryo.
Authors:
A A Ostanin; B I Aizikovich; I V Aizikovich; A Yu Kozhin; E R Chernykh
Related Documents :
10527988 - Intracytoplasmic sperm injection: position of the polar body affects pregnancy rate.
11495408 - Pregnancies resulting from in vitro matured oocytes collected from women with regular m...
17418838 - Repeated pregnancies and live births after in vitro maturation treatment.
9090558 - Endometriosis is not detrimental to embryo implantation in oocyte recipients.
9722178 - Fetal growth and placental function.
12620288 - Maternal and fetal outcomes in pregnancy complicated with acute leukemia: a single inst...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  143     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Affiliation:
Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. ct_lab@mail.ru
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Cytokines / metabolism,  physiology*
Embryo Implantation
Female
Fertilization in Vitro
Follicular Fluid / metabolism
Humans
Infertility / metabolism*,  therapy*
Middle Aged
Oocytes / physiology
Ovulation Induction
Pregnancy
Pregnancy Outcome
Proteomics
Chemical
Reg. No./Substance:
0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of recombinant IL-4delta2 on human peripheral blood mononuclears.
Next Document:  Specificity of relapses and metastases of experimental transplanted Ehrlich carcinoma and B16 melano...