Document Detail

Role of cytokines in the regulation of reproductive function.
MedLine Citation:
PMID:  18019018     Owner:  NLM     Status:  MEDLINE    
The levels of 17 cytokines in the follicular fluid were measured by multiplex proteome analysis at the peak of stimulated ovulation during the in vitro fertilization cycle. In patients with ineffective folliculogenesis, the concentrations of IL-2, IL-4, IL-7, and granulocytic CSF in the follicular fluid were significantly lower than in women with greater mean number of collected oocytes. It was shown that multicomponent cytokine deficit was associated with lower production of high quality oocytes and lower efficiency of fertilization of the resultant oocytes in vitro. The absence of pregnancy after in vitro fertilization cycle is associated with lower levels of IL-2, IL-4, IL-7, granulocytic CSF, and macrophagic inflammatory protein 1b in combination with elevated contents of IL-8 and IL-13. The results attest to an important role of cytokines in the regulation of oogenesis and in preparation of the endometrium to implantation of the embryo.
A A Ostanin; B I Aizikovich; I V Aizikovich; A Yu Kozhin; E R Chernykh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  143     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
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MeSH Terms
Cytokines / metabolism,  physiology*
Embryo Implantation
Fertilization in Vitro
Follicular Fluid / metabolism
Infertility / metabolism*,  therapy*
Middle Aged
Oocytes / physiology
Ovulation Induction
Pregnancy Outcome
Reg. No./Substance:

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