| Role of cytokines in the regulation of reproductive function. | |
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MedLine Citation:
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PMID: 18019018 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The levels of 17 cytokines in the follicular fluid were measured by multiplex proteome analysis at the peak of stimulated ovulation during the in vitro fertilization cycle. In patients with ineffective folliculogenesis, the concentrations of IL-2, IL-4, IL-7, and granulocytic CSF in the follicular fluid were significantly lower than in women with greater mean number of collected oocytes. It was shown that multicomponent cytokine deficit was associated with lower production of high quality oocytes and lower efficiency of fertilization of the resultant oocytes in vitro. The absence of pregnancy after in vitro fertilization cycle is associated with lower levels of IL-2, IL-4, IL-7, granulocytic CSF, and macrophagic inflammatory protein 1b in combination with elevated contents of IL-8 and IL-13. The results attest to an important role of cytokines in the regulation of oogenesis and in preparation of the endometrium to implantation of the embryo. |
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Authors:
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A A Ostanin; B I Aizikovich; I V Aizikovich; A Yu Kozhin; E R Chernykh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 143 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-11-16 Completed Date: 2007-11-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 75-9 Citation Subset: IM |
Affiliation:
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Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. ct_lab@mail.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cytokines / metabolism, physiology* Embryo Implantation Female Fertilization in Vitro Follicular Fluid / metabolism Humans Infertility / metabolism*, therapy* Middle Aged Oocytes / physiology Ovulation Induction Pregnancy Pregnancy Outcome Proteomics |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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