Document Detail

Role of cysteine in corneal wound healing after photorefractive keratectomy.
MedLine Citation:
PMID:  19122468     Owner:  NLM     Status:  MEDLINE    
AIMS: To evaluate the efficacy of cysteine oral supplements in corneal wound healing after photorefractive keratectomy (PRK). METHODS: A total of 200 eyes (100 patients) underwent PRK. We divided patients into 2 groups; each group was composed of 50 patients (100 eyes). Group 1 patients were assigned to use oral L-cysteine, with a daily dose of 200 mg (100-mg pills to be taken twice a day) for a duration of 14 days, starting from the week preceding the operation; the patients in group 2 were used as a control, and received the oral supplementation of 40-mg placebo pills to be taken twice a day for a duration of 14 days, starting from the week preceding the operation. RESULTS: All the eyes of patients treated with cysteine oral supplements showed shorter times to re-epithelization than the eyes of the control group. The mean time of corneal wound healing observed in group 1 was 102 +/- 15 h, compared to an average of 159 +/- 9 h in group 2. CONCLUSION: Our research showed that oral cysteine supplementation, in a daily dose of 200 mg, reduces mean corneal wound healing time in patients after PRK.
Alessandro Meduri; Pier Luigi Grenga; Lucia Scorolli; Piero Ceruti; Giuseppe Ferreri
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-12-20
Journal Detail:
Title:  Ophthalmic research     Volume:  41     ISSN:  1423-0259     ISO Abbreviation:  Ophthalmic Res.     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-28     Completed Date:  2009-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0267442     Medline TA:  Ophthalmic Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  76-82     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Department of Surgical Specialities, Ophthalmology Clinic, University of Messina, Messina, Italy.
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MeSH Terms
Administration, Oral
Cysteine / administration & dosage*
Epithelium, Corneal / drug effects*
Hyperopia / surgery
Lasers, Excimer*
Myopia / surgery
Photorefractive Keratectomy*
Prospective Studies
Single-Blind Method
Time Factors
Wound Healing / drug effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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