| Role of cysteine in corneal wound healing after photorefractive keratectomy. | |
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MedLine Citation:
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PMID: 19122468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate the efficacy of cysteine oral supplements in corneal wound healing after photorefractive keratectomy (PRK). METHODS: A total of 200 eyes (100 patients) underwent PRK. We divided patients into 2 groups; each group was composed of 50 patients (100 eyes). Group 1 patients were assigned to use oral L-cysteine, with a daily dose of 200 mg (100-mg pills to be taken twice a day) for a duration of 14 days, starting from the week preceding the operation; the patients in group 2 were used as a control, and received the oral supplementation of 40-mg placebo pills to be taken twice a day for a duration of 14 days, starting from the week preceding the operation. RESULTS: All the eyes of patients treated with cysteine oral supplements showed shorter times to re-epithelization than the eyes of the control group. The mean time of corneal wound healing observed in group 1 was 102 +/- 15 h, compared to an average of 159 +/- 9 h in group 2. CONCLUSION: Our research showed that oral cysteine supplementation, in a daily dose of 200 mg, reduces mean corneal wound healing time in patients after PRK. |
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Authors:
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Alessandro Meduri; Pier Luigi Grenga; Lucia Scorolli; Piero Ceruti; Giuseppe Ferreri |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2008-12-20 |
Journal Detail:
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Title: Ophthalmic research Volume: 41 ISSN: 1423-0259 ISO Abbreviation: Ophthalmic Res. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-01-28 Completed Date: 2009-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0267442 Medline TA: Ophthalmic Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 76-82 Citation Subset: IM |
Copyright Information:
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(c) 2008 S. Karger AG, Basel. |
Affiliation:
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Department of Surgical Specialities, Ophthalmology Clinic, University of Messina, Messina, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Cysteine / administration & dosage* Epithelium, Corneal / drug effects* Female Humans Hyperopia / surgery Lasers, Excimer* Male Myopia / surgery Photorefractive Keratectomy* Prospective Studies Single-Blind Method Time Factors Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
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52-90-4/Cysteine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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