Document Detail

Role of corticosteroids in the diurnal rhythm of blood pressure.
MedLine Citation:
PMID:  2632749     Owner:  NLM     Status:  MEDLINE    
Blood pressure, a chronobiological parameter, shows a circadian rhythm which parallels the levels of hormones such as glucocorticoids and catecholamines. This rhythm is lost in excess states like Cushing's syndrome or phaeochromocytoma. We designed a double-blind crossover study to look at the role of physiological doses of glucocorticoids in the circadian rhythm of blood pressure. We found no change in the circadian rhythm when 30 mg hydrocortisone (20 + 10 mg versus 10 + 20 mg, a.m./p.m.) was administered.
S G Jyothinagaram; P Neary; D M Watson; I M McGinley; P L Padfield
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  7     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-05-11     Completed Date:  1990-05-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S68-9     Citation Subset:  IM    
University of Edinburgh, Department of Medicine, Western General Hospital, UK.
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MeSH Terms
Addison Disease / physiopathology
Blood Pressure / drug effects*,  physiology
Circadian Rhythm / drug effects*,  physiology
Dose-Response Relationship, Drug
Double-Blind Method
Glucocorticoids / deficiency,  pharmacology*
Hydrocortisone / administration & dosage
Reg. No./Substance:
0/Glucocorticoids; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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