Document Detail


Role of coronary artery calcium score for risk stratification in patients with non significant perfusion defects by myocardial perfusion SPECT.
MedLine Citation:
PMID:  25428736     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Myocardial Perfusion Scintigraphy (MPS) is an important diagnostic tool in the management of patients with suspected coronary artery disease (CAD). However, the presence of mild-moderate perfusion defects can be challenging and may lead to unnecessary cardiac catheterization. The coronary artery calcium (CAC) score is a method with excellent negative predictive value (NPV) in the evaluation of CAD, but its role in this setting of patients has not been fully defined. This study aims to assess the potential of CAC in the prediction of cardiac adverse events in patients with suspected CAD with mild-moderate perfusion by MPS.
METHODS AND RESULTS: We conducted a cohort study in 292 patients presenting with mild-moderate perfusion defects by MPS undergoing a CAC measurement. The patients were followed for a mean of 34 months for occurrence of major cardiac adverse events - MACE. The majority of the patients (64.7 %) were male, mean age of 57.9 ± 12.6 years. During the follow-up there were 37 MACE. In multivariate Cox proportional hazards model, hypertension and CAC were independent predictors of MACE. The patients who presented a CAC score of ≥ 400 had a high risk of MACE (HR 20.9; 95% CI 4.79 to 91.42; p < 0.001). Kaplan-Meier curve showed a significant difference (log-rank χ² ; p< 0.001) using CAC scores in predicting MACE.
CONCLUSIONS: CAC scores carries a powerful prognostic value in predicting adverse events in patients with suspected CAD and MPS with mild-moderate perfusion defects and may be useful in risk stratification of these patients.
Authors:
Márcio Vinícius Lins Barros; Maria do Carmo Pereira Nunes; Gabriel Braga; Daniel Rocha Rabelo; Karen Magalhaes; Fernanda Scaramello; Maria Helena Albernaz Siqueira
Related Documents :
15221506 - Augmented taurine release is not the mechanism of ischemic preconditioning's cardioprot...
8780206 - Endogenous myocardial norepinephrine is not essential for ischemic preconditioning in r...
6526206 - Myocardial infarct size limitation. principles, problems and possibilities.
17459556 - Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: ...
10327326 - Multisite stimulation in refractory heart failure.
15922256 - Erythropoietin mimics ischemic preconditioning.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-27
Journal Detail:
Title:  Cardiology journal     Volume:  -     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-27     Completed Date:  -     Revised Date:  2014-11-28    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A new score system for prediction response to cardiac resynchronization therapy.
Next Document:  Statin-associated myopathy: from genetic predisposition to clinical management.