Document Detail


Role of corin and atrial natriuretic peptide in preeclampsia.
MedLine Citation:
PMID:  23211473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In pregnancy, uterine spiral artery remodeling is an adaptive morphological change at the maternal and fetal interface, which is critical for dilating the artery and promoting blood flow to the fetus. Incompletely remodeled spiral arteries have been recognized as a common pathological feature in preeclamptic patients. To date, the molecular mechanism that controls spiral artery remodeling is not well defined. Corin is a transmembrane serine protease discovered in the heart, where it converts pro-atrial natriuretic peptide (pro-ANP) to active ANP, a cardiac hormone that regulates salt-water balance and blood pressure. Recent studies show that corin is up-regulated in the decidua of the pregnant uterus, suggesting a potential role of corin in pregnancy. In mice lacking corin or ANP, high blood pressure and proteinuria were found at late gestational stages. Histological analysis indicated delayed trophoblast invasion and impaired spiral artery remodeling in the uterus. In humans, CORIN gene mutations were identified in patients with preeclampsia. In this review, we discuss the function of corin and ANP in regulating blood pressure and their potential role in preeclampsia.
Authors:
Y Zhou; Q Wu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-12-02
Journal Detail:
Title:  Placenta     Volume:  34     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-09-06     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Natriuretic Factor / deficiency,  genetics,  physiology*
Disease Models, Animal
Female
Gene Expression
Humans
Mice
Mice, Knockout
Mutation
Pre-Eclampsia / etiology*,  genetics,  physiopathology
Pregnancy
Serine Endopeptidases / deficiency,  genetics,  physiology*
Uterine Artery / pathology,  physiopathology
Uterus / blood supply,  physiopathology
Grant Support
ID/Acronym/Agency:
HD064634/HD/NICHD NIH HHS; HL089298/HL/NHLBI NIH HHS; R01 HD064634/HD/NICHD NIH HHS; R01 HL089298/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor; EC 3.4.21.-/CORIN protein, human; EC 3.4.21.-/Corin protein, mouse; EC 3.4.21.-/Serine Endopeptidases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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