| Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor. | |
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MedLine Citation:
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PMID: 23330547 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The constitutive androstane receptor (CAR, NR1I3) is a member of the nuclear receptor superfamily. Initially recognized as a xenobiotic receptor, CAR has been increasingly appreciated for its endobiotic functions in influencing glucose and lipid metabolism, whose dysregulations are implicated in the most prevalent metabolic disorders, such as obesity and type 2 diabetes. Given the metabolic benefits of CAR activation, CAR may represent an attractive therapeutic target to manage obesity and type 2 diabetes. Further studies are necessary to understand the mechanisms of action of CAR in metabolic diseases and to determine the human relevance of the antidiabetic effect of CAR. |
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Authors:
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Mengxi Jiang; Wen Xie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Drug metabolism reviews Volume: 45 ISSN: 1097-9883 ISO Abbreviation: Drug Metab. Rev. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0322067 Medline TA: Drug Metab Rev Country: England |
Other Details:
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Languages: eng Pagination: 156-63 Citation Subset: IM |
Affiliation:
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Center for Pharmacogenetics and Department of Pharmaceutical Sciences. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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