Document Detail


Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor.
MedLine Citation:
PMID:  23330547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The constitutive androstane receptor (CAR, NR1I3) is a member of the nuclear receptor superfamily. Initially recognized as a xenobiotic receptor, CAR has been increasingly appreciated for its endobiotic functions in influencing glucose and lipid metabolism, whose dysregulations are implicated in the most prevalent metabolic disorders, such as obesity and type 2 diabetes. Given the metabolic benefits of CAR activation, CAR may represent an attractive therapeutic target to manage obesity and type 2 diabetes. Further studies are necessary to understand the mechanisms of action of CAR in metabolic diseases and to determine the human relevance of the antidiabetic effect of CAR.
Authors:
Mengxi Jiang; Wen Xie
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Drug metabolism reviews     Volume:  45     ISSN:  1097-9883     ISO Abbreviation:  Drug Metab. Rev.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-07-16     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  0322067     Medline TA:  Drug Metab Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  156-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Type 2 / genetics,  metabolism*
Humans
Obesity / genetics,  metabolism*
Receptors, Cytoplasmic and Nuclear / genetics,  metabolism*
Xenobiotics / metabolism,  pharmacology
Grant Support
ID/Acronym/Agency:
CA107011/CA/NCI NIH HHS; DK076962/DK/NIDDK NIH HHS; DK083952/DK/NIDDK NIH HHS; ES012479/ES/NIEHS NIH HHS; ES014626/ES/NIEHS NIH HHS; ES019629/ES/NIEHS NIH HHS; R01 DK083952/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Cytoplasmic and Nuclear; 0/Xenobiotics; 0/constitutive androstane receptor

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