Document Detail


Role of connexin 43 in Sertoli cells of testis.
MedLine Citation:
PMID:  17905936     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Connexin 43 (CX43, also known as GJA1) is the predominant testicular gap-junction protein. In the seminiferous epithelium, gap junctions occur between adjacent Sertoli cells and between Sertoli and germ cells. The specific role of CX43 in Sertoli cell has been difficult to study because of the neonatal lethality of the Cx43 global knockout. Recently two laboratories have independently developed a Sertoli cell conditional Cx43 knockout using Cre-loxP methodology. These have allowed the role of CX43 in Sertoli cells to be determined while circumventing lethal abnormalities in organs such as the heart seen in Cx43 global knockouts. In this review the focus is on the insights into the role of CX43 in Sertoli cells derived from these new model systems. Results indicate that CX43 is essential for cessation of proliferation and normal maturation in Sertoli cells. In addition, CX43 in Sertoli cells is required for spermatogenesis, but not early germ cell proliferation. These model systems show that CX43 is important in Sertoli cell development, and will be useful in further studies of its role in Sertoli cell and testis biology.
Authors:
Santhi Sridharan; Ralph Brehm; Martin Bergmann; Paul S Cooke
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2007-09-28
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1120     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-10     Completed Date:  2008-03-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-43     Citation Subset:  IM    
Affiliation:
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / genetics
Cell Differentiation / genetics
Cell Proliferation
Connexin 43 / genetics,  metabolism,  physiology*
Male
Mice
Mice, Knockout
Organ Size / genetics
Organ Specificity / genetics
Sertoli Cells / metabolism*
Spermatogenesis / genetics
Spermatogonia / physiology
Testis / anatomy & histology,  metabolism*
Grant Support
ID/Acronym/Agency:
C06 RR16515/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Connexin 43

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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