| Role of congenital rubella reference laboratory: 21-months-surveillance in Liguria, Italy. | |
| | |
MedLine Citation:
|
PMID: 20812517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: Rubella is generally a mild rush fever disease when acquired in childhood, but when infection occurs during the first months of pregnancy, high risk of trans-placental transmission to the foetus and of congenital anomalies exists. In November 2003, a National Plan for measles and congenital rubella elimination was approved in Italy. The aim was to reduce and maintain Congenital Rubella Syndrome incidence lower than 1 case per 100,000 live births/year by 2007. Since June 2006, Liguria Administrative Region recognized U.O. Hygiene, "San Martino" University Hospital, Genoa, as regional reference laboratory for diagnosis of rubella infection during pregnancy and post-partum. METHODS: Twenty-one-month virological-surveillance results between April 2007 and December 2008 were reported in terms of demographic data, risk factors, access reasons, clinical picture, vaccination, previous rubella disease, laboratory results of pregnant women and newborns. RESULTS AND CONCLUSION: Since the beginning of surveillance, 65 pregnant women with suspected virus infection and 18 newborns with suspected congenital rubella were followed up. The results of laboratory surveillance highlighted (i) the importance of an early screening, (ii) the suboptimal specificity of chemiluminescent assays, that often yield false positive IgM results and (iii) the fundamental role of second-level laboratory to confirm the serological diagnosis and to detect the virus by molecular techniques. |
| | |
Authors:
|
P Canepa; L Valle; E Cristina; D De Florentiis; V Parodi; F Banfi; M Zancolli; P Durando; G Icardi; F Ansaldi |
Related Documents
:
|
1301857 - Patterns of nausea during first trimester of pregnancy. 2200247 - Screening for asymptomatic bacteriuria, hematuria and proteinuria. the u.s. preventive ... 12011887 - Maternal susceptibility to nausea and vomiting of pregnancy: is the vestibular system i... 16338627 - Tetrahydrobiopterin and maternal pku. 964207 - Uterine tubulin production during early pregnancy in the rabbit. 9355947 - Effects of extracorporeal shockwave lithotripsy at different stages of pregnancy in the... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of preventive medicine and hygiene Volume: 50 ISSN: 1121-2233 ISO Abbreviation: J Prev Med Hyg Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2010-09-03 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9214440 Medline TA: J Prev Med Hyg Country: Italy |
Other Details:
|
Languages: eng Pagination: 221-6 Citation Subset: IM |
Affiliation:
|
Doctoral School in Clinical and Experimental Medicine, University of Genoa, Italy. paola.canepa@unige.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Female Humans Immunoglobulin M / metabolism Infant Infant, Newborn Italy / epidemiology Laboratories* Mass Screening / methods* Population Surveillance / methods* Pregnancy Prenatal Diagnosis Reference Standards Rubella Syndrome, Congenital / diagnosis*, prevention & control* Serologic Tests / standards* |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Measles vaccination.
Next Document: Evidence of hepatitis E virus (HEV) infection in human and pigs in Sardinia, Italy.