Document Detail


Role of congenital long-QT syndrome in unexplained sudden infant death: proposal for an electrocardiographic screening in relatives.
MedLine Citation:
PMID:  19266217     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Congenital long-QT syndrome (LQTS) is a sporadic or familial inherited arrhythmia. It can lead to sudden death by ventricular fibrillation which occurs at any age but particularly during infancy. Recent studies of postmortem molecular analysis in infants who died of unexplained sudden infant death syndrome (SIDS) showed abnormal mutations to LQTS in 10% to 12%. Current methods of etiologic investigation of sudden infant death syndrome do not allow the diagnosis of LQTS. A targeted anamnesis together with systematic electrocardiograms of first- and second-degree relatives could be an efficient LQTS diagnostic tool. Therefore, we propose to include them in screening procedures for SIDS etiologies.
CONCLUSION: LQTS accounts for a significant number of unexplained SIDS. We suggest adding a systematic familial electrocardiographic screening to the current etiologic investigations in order to track congenital LQTS in relatives.
Authors:
Alban-Elouen Baruteau; Julien Baruteau; Ryad Joomye; Raphael Martins; Frédéric Treguer; Remi Baruteau; Jean-Claude Daubert; Philippe Mabo; Michel Roussey
Related Documents :
3977387 - Diaphragmatic paralysis due to spinal muscular atrophy. an unrecognised cause of respir...
12694297 - New insights in uremic toxins.
8230167 - Airway abnormalities in jarcho-levin syndrome: a report of two cases.
1512667 - Rigid gas permeable contact lens correction of aphakia following congenital cataract re...
22258087 - Neonatal and infant outcome in boys and girls born very prematurely.
20079477 - Route of delivery and neonatal birth trauma.
Publication Detail:
Type:  Journal Article; Review     Date:  2009-03-06
Journal Detail:
Title:  European journal of pediatrics     Volume:  168     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-08-19     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  771-7     Citation Subset:  IM    
Affiliation:
CHU Rennes, Service de Cardiologie et Maladies Vasculaires, Rennes, France. alban.baruteau@wanadoo.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Electrocardiography*
Family*
Genetic Predisposition to Disease
Humans
Infant
Infant, Newborn
Long QT Syndrome / complications*,  congenital,  diagnosis*,  physiopathology
Postmortem Changes
Risk Factors
Sudden Infant Death / etiology*
Ventricular Fibrillation / complications*,  etiology,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Meningitis with subdural empyema due to non-typhoid Salmonella in a 9-month-old girl.
Next Document:  MlcR, a zinc cluster activator protein, is able to bind to a single (A/T)CGG site of cognate asymmet...