Document Detail

Role of congenital long-QT syndrome in unexplained sudden infant death: proposal for an electrocardiographic screening in relatives.
MedLine Citation:
PMID:  19266217     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Congenital long-QT syndrome (LQTS) is a sporadic or familial inherited arrhythmia. It can lead to sudden death by ventricular fibrillation which occurs at any age but particularly during infancy. Recent studies of postmortem molecular analysis in infants who died of unexplained sudden infant death syndrome (SIDS) showed abnormal mutations to LQTS in 10% to 12%. Current methods of etiologic investigation of sudden infant death syndrome do not allow the diagnosis of LQTS. A targeted anamnesis together with systematic electrocardiograms of first- and second-degree relatives could be an efficient LQTS diagnostic tool. Therefore, we propose to include them in screening procedures for SIDS etiologies.
CONCLUSION: LQTS accounts for a significant number of unexplained SIDS. We suggest adding a systematic familial electrocardiographic screening to the current etiologic investigations in order to track congenital LQTS in relatives.
Alban-Elouen Baruteau; Julien Baruteau; Ryad Joomye; Raphael Martins; Frédéric Treguer; Remi Baruteau; Jean-Claude Daubert; Philippe Mabo; Michel Roussey
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-03-06
Journal Detail:
Title:  European journal of pediatrics     Volume:  168     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-08-19     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  771-7     Citation Subset:  IM    
CHU Rennes, Service de Cardiologie et Maladies Vasculaires, Rennes, France.
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MeSH Terms
Genetic Predisposition to Disease
Infant, Newborn
Long QT Syndrome / complications*,  congenital,  diagnosis*,  physiopathology
Postmortem Changes
Risk Factors
Sudden Infant Death / etiology*
Ventricular Fibrillation / complications*,  etiology,  physiopathology

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