Document Detail

Role of composite endpoints as an outcome assessment tool in urogenital prolapse.
MedLine Citation:
PMID:  22369404     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: POP-Q ordinal = 0 (pelvic organ prolapse quantification system); (2) Subjective: PGI-I = 1 or 2 (patient global impression of improvement); (3) Composite endpoint of cure: POP-Q ordinal = zero and patient goal achievement = 60%. Our results showed 'Composite cure' of POP was in 88.7%, while objective and subjective cure were 85.3% and 95.5%, respectively. Defining 'success' or 'failures' based on PGI-I scores was most discriminatory. Quality of life (QoL) was similar in treatment success or failure groups, where cure was measured objectively or using the composite endpoint. Composite endpoints should accurately represent cure as they combine objective measures and patient goals. However, these were not demonstrated as valid methods in defining success of prolapse surgery.
S Srikrishna; D Robinson; L Cardozo
Related Documents :
7631024 - Irradiation of bone metastases in breast cancer patients: a randomized study with 1 yea...
12753274 - Usefulness of pamidronate in severe secondary hyperparathyroidism in patients undergoin...
14678294 - Growth hormone replacement in adults and bone mineral density: a systematic review and ...
8501744 - Metabolic bone status in young women with juvenile chronic arthritis.
16123914 - Ximelagatran for the prevention of venous thromboembolism following elective hip or kne...
24995084 - Influence of the design in sagittal split ramus osteotomy on the mechanical behavior.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  32     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-02-28     Completed Date:  2012-07-27     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  276-9     Citation Subset:  IM    
Department of Urogynaecology, King's College Hospital, Denmark Hill, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Follow-Up Studies
Hysterectomy, Vaginal*
Middle Aged
Pelvic Floor / surgery*
Pelvic Organ Prolapse / surgery*
Prospective Studies
Quality of Life*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A population-based case-control study of aetiological factors associated with vulval lichen sclerosu...
Next Document:  Comparison of the clinical and quality-of-life outcomes after the inside-out TVT-O procedure with or...