Document Detail

Role of composite endpoints as an outcome assessment tool in urogenital prolapse.
MedLine Citation:
PMID:  22369404     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: POP-Q ordinal = 0 (pelvic organ prolapse quantification system); (2) Subjective: PGI-I = 1 or 2 (patient global impression of improvement); (3) Composite endpoint of cure: POP-Q ordinal = zero and patient goal achievement = 60%. Our results showed 'Composite cure' of POP was in 88.7%, while objective and subjective cure were 85.3% and 95.5%, respectively. Defining 'success' or 'failures' based on PGI-I scores was most discriminatory. Quality of life (QoL) was similar in treatment success or failure groups, where cure was measured objectively or using the composite endpoint. Composite endpoints should accurately represent cure as they combine objective measures and patient goals. However, these were not demonstrated as valid methods in defining success of prolapse surgery.
S Srikrishna; D Robinson; L Cardozo
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  32     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-02-28     Completed Date:  2012-07-27     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  276-9     Citation Subset:  IM    
Department of Urogynaecology, King's College Hospital, Denmark Hill, London, UK.
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MeSH Terms
Aged, 80 and over
Follow-Up Studies
Hysterectomy, Vaginal*
Middle Aged
Pelvic Floor / surgery*
Pelvic Organ Prolapse / surgery*
Prospective Studies
Quality of Life*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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