Document Detail


Role of cyclinT/Cdk9 complex in basal and regulated transcription (review).
MedLine Citation:
PMID:  12063565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell division and proliferation of all eukaryotics must follow a genetic program, termed the cell cycle. To ensure proper progression through the cell cycle, proteins that are intimately involved in its regulation must be periodically expressed within an appropriate window of the cycle. Cyclin and cyclin-dependent kinases are the modular components of the core clock machinery of the cell cycle. Progression through the cell cycle requires the activation of Cdks. The activities of these classes of kinases are tightly regulated by both positive and negative factors, and most importantly perturbation of Cdk activities can result in tumorigenesis. Progress has been made recently in connecting specific cyclin-Cdk kinase complexes and transcription. It is still unclear how cyclin/Cdk complexes regulate transcription, and most importantly what their substrates are. The aim of this review is to discuss our current understanding of the molecular mechanisms underlying the transcription properties of defined cyclin-dependent kinases, with a particular emphasis on the cyclin T/Cdk9 (P-TEFb) complex, and its role in the regulation of cell cycle controlling genes.
Authors:
Giuliana Napolitano; Barbara Majello; Luigi Lania
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International journal of oncology     Volume:  21     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-13     Completed Date:  2002-12-02     Revised Date:  2012-06-20    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  171-7     Citation Subset:  IM    
Affiliation:
Department of Genetics, Molecular and General Biology, University of Naples Federico II, 80134 Naples, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle / physiology*
Cyclin T
Cyclin-Dependent Kinase 9
Cyclin-Dependent Kinases / genetics,  metabolism*
Cyclins / genetics,  metabolism*
Gene Expression Regulation / physiology*
Humans
Transcription, Genetic
Chemical
Reg. No./Substance:
0/CCNT1 protein, human; 0/Cyclin T; 0/Cyclins; EC 2.7.11.22/CDK9 protein, human; EC 2.7.11.22/Cyclin-Dependent Kinase 9; EC 2.7.11.22/Cyclin-Dependent Kinases

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