Document Detail

Role of the ATFa/JNK2 complex in Jun activation.
MedLine Citation:
PMID:  10376527     Owner:  NLM     Status:  MEDLINE    
The ATFa proteins, which are members of the CREB/ATF family of transcription factors, display quite versatile properties. We have previously shown that they interact with the adenovirus E1a oncoprotein, mediating part of its transcriptional activity and heterodimerize with the Jun, Fos or related transcription factors, thereby modulating their DNA-binding specificity. In the present study, we report the sequence requirement of the N-terminal activation domain of ATFa and demonstrate the importance of specific threonine residues (Thr51 and Thr53) in addition to that of the metal-binding domain, in transcriptional activation processes. We also show that the N-terminal domain of ATFa which stably binds the Jun N-terminal kinase-2 (JNK2) (Bocco et al., 1996), is not a substrate for this kinase in vivo but, instead, serves as a JNK2-docking site for ATFa-associated partners like JunD, allowing them to be phosphorylated by the bound kinase.
F De Graeve; A Bahr; K T Sabapathy; C Hauss; E F Wagner; C Kedinger; B Chatton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Oncogene     Volume:  18     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-06-30     Completed Date:  1999-06-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3491-500     Citation Subset:  IM    
Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM/CNRS/ULP, Illkirch, CU de Strasbourg, France.
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MeSH Terms
Activating Transcription Factor 1
COS Cells
Cell Line
DNA-Binding Proteins*
Mitogen-Activated Protein Kinase 9
Mitogen-Activated Protein Kinases*
Peptide Fragments / physiology*
Protein Kinases / physiology*
Proto-Oncogene Proteins c-jun / metabolism
Transcription Factors / physiology*
Transcriptional Activation / physiology*
Reg. No./Substance:
0/Activating Transcription Factor 1; 0/DNA-Binding Proteins; 0/Peptide Fragments; 0/Proto-Oncogene Proteins c-jun; 0/Transcription Factors; EC 2.7.-/Protein Kinases; EC Protein Kinase 9; EC Protein Kinases

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