| Role of the commensal microbiota in normal and pathogenic host immune responses. | |
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MedLine Citation:
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PMID: 22018232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The commensal microbiota that inhabit different parts of the gastrointestinal (GI) tract have been shaped by coevolution with the host species. The symbiotic relationship of the hundreds of microbial species with the host requires a tuned response that prevents host damage, e.g., inflammation, while tolerating the presence of the potentially beneficial microbes. Recent studies have begun to shed light on immunological processes that participate in maintenance of homeostasis with the microbiota and on how disturbance of host immunity or the microbial ecosystem can result in disease-provoking dysbiosis. Our growing appreciation of this delicate host-microbe relationship promises to influence our understanding of inflammatory diseases and infection by microbial pathogens and to provide new therapeutic opportunities. |
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Authors:
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Dan R Littman; Eric G Pamer |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cell host & microbe Volume: 10 ISSN: 1934-6069 ISO Abbreviation: Cell Host Microbe Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-24 Completed Date: 2012-02-08 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 101302316 Medline TA: Cell Host Microbe Country: United States |
Other Details:
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Languages: eng Pagination: 311-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. dan.littman@med.nyu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gastrointestinal Tract / immunology*, microbiology* Humans Metagenome / immunology*, physiology* Models, Biological Symbiosis* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI042135/AI/NIAID NIH HHS; R01 AI042135-15/AI/NIAID NIH HHS; R01 AI080619/AI/NIAID NIH HHS; RC2 AR058986/AR/NIAMS NIH HHS; RC2 AR058986-02/AR/NIAMS NIH HHS; //Howard Hughes Medical Institute |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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