| Role of circulating immune-complexes as prognostic indicators of lympho-reticular and mesenchymal malignancies in children. | |
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MedLine Citation:
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PMID: 1527815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Circulating immune complexes (CIC) were estimated in 28 cases of Non-Hodgkin's lymphomas, Hodgkin's disease, bone and soft tissue sarcomas in the pediatric age group by polyethylene glycol (PEG) precipitation and latex agglutination inhibition (LAI) techniques. Results were compared with 25 age-matched controls. Highly significant CIC values were obtained by LAI technique (P less than 0.01) as compared to PEG pptn technique (P less than 0.05) in malignancy. However, seropositivity for CIC in lymphomas and Hodgkin's disease was 85.71 per cent by LAI test as compared to 57.14 per cent by PEG pptn test. In sarcoma group, seropositivity for CIC was 57.11 per cent by LAI test and 28.57 per cent by PEG pptn test. Combination of both these tests increases the sensitivity of immune complex detection in serum of cancer patients. CIC begin to rise in serum in early stages of neoplastic transformation, and the level of CIC is directly proportional to proliferating tumour mass in vivo. |
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Authors:
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M Aziz; T K Dass; A Rattan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of tropical pediatrics Volume: 38 ISSN: 0142-6338 ISO Abbreviation: J. Trop. Pediatr. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-10-22 Completed Date: 1992-10-22 Revised Date: 2006-03-28 |
Medline Journal Info:
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Nlm Unique ID: 8010948 Medline TA: J Trop Pediatr Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 185-8 Citation Subset: IM |
Affiliation:
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Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigen-Antibody Complex
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immunology* Child Female Fluorescent Antibody Technique Hodgkin Disease / diagnosis*, immunology Humans Lymphoma / diagnosis*, immunology Male Prognosis Sarcoma / diagnosis*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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