Document Detail


Role of ciclosporin in steroid-responsive sudden sensorineural hearing loss.
MedLine Citation:
PMID:  16303687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSIONS: A subgroup of patients with idiopathic sensorineural hearing loss (SNHL) will have steroid-dependent symptoms which can be confirmed using pure-tone audiometry. Long-term treatment with high-dose corticosteroids exposes patients to potentially serious adverse effects. Immunosuppression with ciclosporin can be an effective and well-tolerated treatment for steroid-responsive sudden SNHL. OBJECTIVE: To highlight ciclosporin as a therapeutic option in the treatment of steroid-responsive sudden SNHL. MATERIAL AND METHODS: A 39-year-old male with idiopathic sudden SNHL that was responsive to corticosteroids was treated with ciclosporin for 18 months. RESULTS: Steroid-dependent SNHL was confirmed on audiological evaluation. Ciclosporin was administered, allowing corticosteroid therapy to be discontinued. Ciclosporin was effective at controlling all symptoms of SNHL. Remission was confirmed objectively with pure-tone audiometry.
Authors:
Lisha McClelland; Richard J Powell; John Birchall
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  125     ISSN:  0001-6489     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1356-60     Citation Subset:  IM    
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Queen's Medical Centre, Nottingham, UK. lisha@orange.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Alopecia / drug therapy
Audiometry, Pure-Tone
Cyclosporine / therapeutic use*
Dose-Response Relationship, Drug
Drug Administration Schedule
Finasteride / adverse effects*,  therapeutic use
Follow-Up Studies
Hearing Loss, Sensorineural / chemically induced*,  diagnosis,  drug therapy*
Hearing Loss, Sudden / chemically induced*,  diagnosis,  drug therapy*
Humans
Male
Risk Assessment
Severity of Illness Index
Treatment Outcome
Chemical
Reg. No./Substance:
59865-13-3/Cyclosporine; 98319-26-7/Finasteride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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