Document Detail

Role of cholinergic and adrenergic pathways of the medial septal area in the water intake and pressor response to central angiotensin II and carbachol in rats.
MedLine Citation:
PMID:  7633894     Owner:  NLM     Status:  MEDLINE    
In the present study, we investigated the effect of previous injection of either prazosin (alpha 1-adrenergic antagonist) or atropine (muscarinic cholinergic antagonist) into the medial septal area (MSA) on the pressor and dipsogenic response induced by intracerebroventricular (ICV) injection of carbachol (cholinergic agonist) and angiotensin II (ANGII) in rats. The pressor and dipsogenic responses to ICV carbachol (7 nmol) were reduced after previous treatment of the MSA with atropine (0.5 to 5 nmol), but not prazosin (20 and 40 nmol). The dipsogenic response to ICA ANGII (25 ng) was reduced after prazosin (40 nmol) into the MSA. The pressor response to ICV ANGII was not changed either by previous treatment of the MSA with prazosin or atropine. The present results suggest a dissociation among the pathways subserving the control of dipsogenic and pressor responses to central cholinergic or angiotensinergic activation.
S P Barbosa; J I de Gobbi; L Zilioli; L A Camargo; W A Saad; A Renzi; L A de Luca Júnior; J V Menani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research bulletin     Volume:  37     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1995  
Date Detail:
Created Date:  1995-09-08     Completed Date:  1995-09-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  463-6     Citation Subset:  IM    
Department of physiology, School of Dentistry, Paulista State University, UNESP, Araraquara, Brazil.
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MeSH Terms
Angiotensin II / administration & dosage,  antagonists & inhibitors,  pharmacology*
Atropine / pharmacology
Autonomic Pathways / physiology*
Blood Pressure / drug effects*
Brain / anatomy & histology,  physiology
Carbachol / administration & dosage,  antagonists & inhibitors,  pharmacology*
Drinking / drug effects*
Injections, Intraventricular
Parasympathetic Nervous System / physiology*
Prazosin / pharmacology
Sympathetic Nervous System / physiology*
Reg. No./Substance:
11128-99-7/Angiotensin II; 19216-56-9/Prazosin; 51-55-8/Atropine; 51-83-2/Carbachol

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