Document Detail

Role of cholecystokinin in relaxation of the proximal stomach.
MedLine Citation:
PMID:  11336159     Owner:  NLM     Status:  MEDLINE    
Ingestion of a meal causes proximal gastric relaxation (accommodation). The magnitude of accommodation is related to the fat content of the meal. A role for cholecystokinin (CCK) has been suggested. However, under fasting conditions intravenous CCK to postprandial levels does not induce a similar accommodation. This study further explores the role of CCK in accommodation. A gastric barostat was used in eight healthy persons to study accommodation in response to a carbohydrate meal with intravenous CCK (CH-CCK), carbohydrate meal with intravenous placebo (CH-placebo) and a fat rich meal with intravenous placebo (FAT). VAS scores for satiety and plasma CCK levels were obtained. In the first postprandial hour the FAT meal induced a relaxation of 112 +/- 29 ml, the CH-CCK meal 49 +/- 36 ml and the CH-placebo meal 12 +/- 32 ml (FAT versus CH-placebo P = 0.03; FAT versus CH-CCK P = 0.09). In the second postprandial hour, intragastric bag volume returned to baseline with all meals. The FAT meal had the most pronounced effect with respect to satiety, CH-placebo the least. In the first postprandial hour, plasma CCK levels increased with the CH-CCK and FAT meals but not with the CH-placebo meal; in the second postprandial hour, levels remained elevated with the CH-CCK meal. It is concluded that a carbohydrate meal with exogenous CCK does not induce fundic relaxation, whereas a fat-rich meal (endogenous CCK) does, despite similar plasma CCK levels.
P J van der Schaar; Y Bremer; C B Lamers; A A Masclee
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  36     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-04     Completed Date:  2001-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  361-6     Citation Subset:  IM    
Dept. of Gastroenterology-Hepatology, Leiden University Medical Center, The Netherlands.
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MeSH Terms
Cholecystokinin / administration & dosage,  metabolism*
Dietary Carbohydrates / administration & dosage*
Dietary Fats / administration & dosage*
Digestion / drug effects,  physiology
Gastrointestinal Motility / physiology*
Injections, Intravenous
Multivariate Analysis
Muscle Relaxation / physiology
Postprandial Period / physiology*
Reference Values
Sensitivity and Specificity
Stomach / drug effects,  physiology*
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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