| Role of cholecystokinin in the intestinal phase of pancreatic circulation in dogs. | |
| | |
MedLine Citation:
|
PMID: 11254487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The regulatory mechanisms of postprandial pancreatic hyperemia are not well characterized. The aim of this study is to clarify the role of cholecystokinin (CCK) in the intestinal phase of pancreatic circulation. Pancreatic, gastric, and intestinal blood flows were measured by ultrasound transit-time blood flowmeters in five conscious dogs. Pancreatic and gastric secretion and blood pressure were also monitored. Synthetic CCK octapeptide (CCK-8) or gastrin heptadecapeptide (gastrin-17) was infused intravenously, and milk was infused into the duodenum with or without loxiglumide, a specific CCK-A receptor antagonist. CCK-8 induced dose-related increases of pancreatic, but not gastric or intestinal, blood flow and protein secretion without affecting systemic blood pressure. Gastrin-17 did not affect pancreatic blood flow. An intraduodenal infusion of milk increased pancreatic and intestinal blood flows and pancreatic protein secretion. Loxiglumide completely inhibited pancreatic blood flow and protein responses to CCK-8 and milk but not the intestinal blood flow response. CCK is a potent and specific pancreatic vasodilator, with its effect mediated by CCK-A receptors. CCK plays an important role in the regulation of the intestinal phase of the pancreatic circulation in dogs. |
| | |
Authors:
|
M Nakajima; S Naruse; M Kitagawa; H Ishiguro; C Jin; O Ito; T Hayakawa |
Related Documents
:
|
22436247 - Studies of isolated global brain ischaemia: iii. influence of pulsatile flow during cer... 20863267 - Lymphatic pump treatment increases thoracic duct lymph flow in conscious dogs with edem... 3768567 - Effect of acute hypoxia on lung fluid balance in the prerecruited dog lung. 844147 - Distribution of coronary artery flow to the canine right atrium and sinoatrial node. 21494177 - Peripheral blood sampling for the detection of allograft rejection: biomarker identific... 5960807 - Fractionation of spinach chloroplasts by flow sedimentation--electrophoresis. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 280 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2001 Apr |
Date Detail:
|
Created Date: 2001-03-20 Completed Date: 2001-04-19 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: G614-20 Citation Subset: IM |
Affiliation:
|
Internal Medicine II, Nagoya University School of Medicine, Nagoya 466-8550, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cholecystokinin / blood, metabolism, physiology* Dogs Female Hemodynamics / physiology Hormone Antagonists / pharmacology Intestines / blood supply* Male Milk / physiology Pancreas / blood supply*, secretion Proglumide / analogs & derivatives*, pharmacology Proteins / metabolism Receptor, Cholecystokinin A Receptors, Cholecystokinin / antagonists & inhibitors Regional Blood Flow / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Hormone Antagonists; 0/Proteins; 0/Receptor, Cholecystokinin A; 0/Receptors, Cholecystokinin; 107097-80-3/loxiglumide; 6620-60-6/Proglumide; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sulfate and chloride transport in Caco-2 cells: differential regulation by thyroxine and the possibl...
Next Document: Lactase synthesis is pretranslationally regulated in protein-deficient pigs fed a protein-sufficient...