| Role of cholecystokinin in the control of nociception and food intake. | |
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MedLine Citation:
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PMID: 4080709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intraperitoneal administration of cholecystokinin (CCK) potently attenuated opiate analgesia produced by footshock. CCK also inhibited opiate footshock analgesia when delivered intrathecally to the lumbosacral spinal cord, a critical site of opiate action in mediating this form of analgesia. However, opiate-independent footshock analgesia was not attenuated by CCK. Morphine analgesia was attenuated by CCK and potentiated by sequestration of peripheral CCK through an active immunization procedure. CCK also was found to suppress food intake in rats when microinjected into the hypothalamic paraventricular nucleus, a site known to mediate opiate-induced feeding. Collectively, the findings reviewed here suggest that an opiate antagonistic action may underlie several of the effects of CCK. |
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Authors:
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P L Faris |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Progress in clinical and biological research Volume: 192 ISSN: 0361-7742 ISO Abbreviation: Prog. Clin. Biol. Res. Publication Date: 1985 |
Date Detail:
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Created Date: 1986-02-07 Completed Date: 1986-02-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7605701 Medline TA: Prog Clin Biol Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 159-66 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia Animals Dose-Response Relationship, Drug Drug Tolerance Electroshock Feeding Behavior / drug effects* Morphine / pharmacology Nociceptors / drug effects, physiology* Rats Sincalide / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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ES07066/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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25126-32-3/Sincalide; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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