Document Detail


Role of chemokines in severe asthma.
MedLine Citation:
PMID:  16719768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The severe asthma phenotype is exhibited by a subset of asthma patients whose asthma symptom is poorly controlled by current therapies. Severe asthma represents a high unmet medical need and warrants research into the mechanisms driving the underlying pathophysiology. It is hypothesized that the underlying pathology associated with severe asthma is driving the symptoms experienced by these patients, which may share common features with mild to moderate asthma or may represent a unique pathological phenotype. For the purpose of this review, the pathophysiology associated with asthma in general are described and extended to incorporate severe asthma. Chemokines may contribute towards multiple features of asthma pathophysiology and this current review focuses on the biology of chemokines pertaining to asthma pathophysiology. Chemokines are important recruiters and activators of inflammatory cells and these infiltrating cells interact with resident cells, such as fibroblasts and it is through these pathways that chemokines appear to exert multiple biological actions. Clinical trials are underway with therapeutics targeting chemokine pathways for other inflammatory diseases. It is hoped that the information generated from these studies will contribute towards furthering our understanding of chemokine biology and be applied towards targeting severe asthma.
Authors:
L A Murray; F Syed; L Li; D E Griswold; A M Das
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current drug targets     Volume:  7     ISSN:  1389-4501     ISO Abbreviation:  Curr Drug Targets     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-24     Completed Date:  2006-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960531     Medline TA:  Curr Drug Targets     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  579-88     Citation Subset:  IM    
Affiliation:
Department of Immunobiology, Centocor Inc., 145 King of Prussia Road, Radnor, PA 19087, USA. LMurra12@CNTUS.JNJ.COM
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MeSH Terms
Descriptor/Qualifier:
Animals
Asthma / etiology*,  pathology,  physiopathology
Basophils / physiology
Bronchi / pathology
Chemokines / physiology*
Eosinophils / physiology
Epithelial Cells / pathology
Fibroblasts / pathology
Fibrosis
Humans
Hypertrophy
Mast Cells / physiology
Myocytes, Smooth Muscle / pathology
Neovascularization, Physiologic
Neutrophils / physiology
T-Lymphocytes / physiology
Chemical
Reg. No./Substance:
0/Chemokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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