| Role of cerebellar cortical protein synthesis in transfer of memory trace of cerebellum-dependent motor learning. | |
| | |
MedLine Citation:
|
PMID: 21677179 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
We developed a new protocol that induces long-term adaptation of horizontal optokinetic response (HOKR) eye movement by hours of spaced training and examined the role of protein synthesis in the cerebellar cortex in the formation of memory of adaptation. Mice were trained to view 800 cycles of screen oscillation either by 1 h of massed training or by 2.5 h to 8 d of training with 0.5 h to 1 d space intervals. The HOKR gains increased similarly by 20-30% at the end of training; however, the gains increased by 1 h of massed training recovered within 24 h, whereas the gains increased by spaced training were sustained over 24 h. Bilateral floccular lidocaine microinfusions immediately after the end of training recovered the gains increased by 1 h of massed training but did not affect the gains increased by 4 h of spaced training, suggesting that the memory trace of adaptation was transferred from the flocculus to the vestibular nuclei within 4 h of spaced training. Blockade of floccular protein synthesis, examined by bilateral floccular microinfusions of anisomycin or actinomycin D 1-4 h before the training, impaired the gains increased by 4 h of spaced training but did not affect the gains increased by 1 h of massed training. These findings suggest that the transfer of the memory trace of adaptation occurs within 4 h of spaced training, and proteins synthesized in the flocculus during training period may play an important role in memory transfer. |
| | |
Authors:
|
Takehito Okamoto; Shogo Endo; Tomoaki Shirao; Soichi Nagao |
Related Documents
:
|
11051929 - Student nurses' learning needs & expectations in the clinical learning units. 7873899 - Epsdt model training program. 8081699 - Socializing culturally diverse students: a historically black university's nursing educ... 10718889 - An evaluation of process and outcomes from learning through reflective practice groups ... 6561249 - Developing prospective managers. part 1. a unique project. 11381359 - Preceptors: a perspective of what works. 14741989 - Clinical governance and the development of a new professionalism in medicine: education... 7073029 - Pediatric training in emergency medicine residency programs. 21752169 - Sex education during the school-aged years influences sexual attitudes and sexual healt... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 31 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-06-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
|
Languages: eng Pagination: 8958-66 Citation Subset: IM |
Affiliation:
|
Laboratory for Motor Learning Control, RIKEN Brain Science Institute, Hirosawa, Wako, Saitama 351-0198, Japan, Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Showa-machi, Maebashi, Gunma 371-8511, Japan, Aging Regulation Research Team, Tokyo Metropolitan Institute of Gerontology, Itabashi, Tokyo 173-0015, Japan, and Solution-Oriented Research for Science and Technology, Japan Science and Technology Corporation, Honcho, Kawaguchi, Saitama, 332-0012, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulation of extrasynaptic 5-HT by serotonin reuptake transporter function in 5-HT-absorbing neuron...
Next Document: Asymmetry of parietal interhemispheric connections in humans.