Document Detail

Role of central serotonergic (5-HT2) receptor in blood pressure regulation in rats.
MedLine Citation:
PMID:  3243000     Owner:  NLM     Status:  MEDLINE    
To investigate the role of the serotonergic nervous system in blood pressure regulation, 5 micrograms of 5-hydroxytryptamine (5-HT) was given i.c.v. before and after 1 microgram of i.c.v. xylamidine or 200 micrograms of i.c.v. ketanserin or 200 micrograms of i.v. ketanserin in conscious Wistar Kyoto rats. Also i.v. (0.5, 1, 2 micrograms) or i.c.v. (1 microgram) phenylephrine (PHE) were given before and after 1 microgram of i.c.v. xylamidine. I.c.v. 5-HT elicited a consistent pressor response of approximately 27mmHg and slight decrease in heart rate. MAP and heart rate did not change after xylamidine or ketanserin. Whereas pressor response to i.c.v. 5-HT after i.c.v. ketanserin or i.c.v. xylamidine was suppressed, it did not change after i.v. ketanserin. Neither i.c.v. nor i.v. PHE-induced pressor response was influenced by i.c.v. xylamidine pretreatment. These data suggest that the central 5-HT2 receptor may subserve pressor function in rats.
T Kushiro; H Kurumatani; T Ishii; H Yokoyama; J Koike; Y Hatayama; Y Kobayashi; N Kajiwara
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  10 Suppl 1     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-30     Completed Date:  1989-05-30     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-45     Citation Subset:  IM    
Dept. of Cardiology, Surugadai Nihon University Hospital, Tokyo, Japan.
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MeSH Terms
Amidines / pharmacology
Blood Pressure* / drug effects
Brain / physiology*
Ketanserin / pharmacology
Rats, Inbred Strains
Rats, Inbred WKY
Receptors, Serotonin / physiology*
Reg. No./Substance:
0/Amidines; 0/Receptors, Serotonin; 6443-50-1/xylamidine; 74050-98-9/Ketanserin

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