Document Detail

Role of cellular immunity in the pathogenesis of autoimmune skin diseases.
MedLine Citation:
PMID:  16466620     Owner:  NLM     Status:  MEDLINE    
The pathomechanism of most autoimmune skin diseases is still elusive; however, recent clinical and basic research is leading novel insights into the cellular and molecular biological underlying pathways. Several types of infectious skin diseases are infiltrated by significant number of gamma/delta T cells and similar observations have been made in selected immune-mediated skin conditions. In particular, a role for gamma/delta T cells has been suggested in discoid lupus erythematosus, contact dermatitis, herpetiformis dermatitis, necrotizing cutaneous vasculitis, and cutaneous lesions of systemic sclerosis. The pathogenesis of these diseases is different and this may suggest multiple potential functions of this subset of T cells in the immune system of the skin. Furthermore, most T cells infiltrating tissue and organs undergoing fibrosis have the potential to produce high levels of interleukin 4. This is particularly true for the CD8+ or CD4+ CD8+ double positive T-cell subsets. Furthermore, leukocyte recruitment is a key event in immunity and a better understanding of the signals involved in autoimmune diseases constitutes a valuable basis for the development of new strategies, which control leukocyte migration and function under pathological conditions.
M Alaibac; E Berti; C Chizzolini; S Fineschi; A V Marzano; B Pigozzi; E Riboldi; S Sozzani; A Kuhn
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  24     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-02-09     Completed Date:  2006-06-15     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S14-9     Citation Subset:  IM    
Unit of Dermatology, University of Padua, Padua, Italy.
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MeSH Terms
Apoptosis / immunology
Autoimmune Diseases / etiology,  immunology*
Fibroblasts / immunology
Immunity, Cellular / immunology*
Scleroderma, Systemic / immunology
Skin Diseases / etiology,  immunology*
T-Lymphocyte Subsets / immunology
T-Lymphocytes / immunology*

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