Document Detail

Role of cells and mediators in exercise-induced bronchoconstriction.
MedLine Citation:
PMID:  23830127     Owner:  NLM     Status:  MEDLINE    
A susceptible group of subjects with asthma develops airflow obstruction in response to the transfer of water out of the airways during exercise. The transfer of water or the challenge with a hypertonic solution serves as a strong stimulus to the airway epithelium. Susceptible subjects have epithelial shedding into the airway lumen, and airway inflammation that leads to the overproduction of leukotrienes and other eicosanoids following exercise challenge. The sensory nerves of the airways may serve as a critical link that mediates the effect of eicosanoids, leading to bronchoconstriction and mucus production in response to exercise challenge.
Teal S Hallstrand; William A Altemeier; Moira L Aitken; William R Henderson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-03-29
Journal Detail:
Title:  Immunology and allergy clinics of North America     Volume:  33     ISSN:  1557-8607     ISO Abbreviation:  Immunol Allergy Clin North Am     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-08     Completed Date:  2014-02-17     Revised Date:  2014-08-04    
Medline Journal Info:
Nlm Unique ID:  8805635     Medline TA:  Immunol Allergy Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  313-28, vii     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Airway Remodeling
Asthma, Exercise-Induced / etiology*
Eicosanoids / biosynthesis
Inflammation Mediators / metabolism
Leukocytes / immunology,  metabolism
Respiratory Mucosa / immunology,  metabolism
Respiratory System / immunology,  innervation,  metabolism
Grant Support
Reg. No./Substance:
0/Eicosanoids; 0/Inflammation Mediators

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