| Role of cell-mediated immunity in chlamydial infection: implications for ocular immunity. | |
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MedLine Citation:
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PMID: 4070909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cellular immunity to Chlamydia trachomatis is not well understood. Studies with the mouse pneumonitis agent in a mouse pneumonia model suggest a strong thymic component to immunity and a role for the macrophage as an effector cell in cell-mediated immunity to C. trachomatis. Experiments with Chlamydia psittaci indicate that cellular cytotoxic mechanisms and biostatic or cytotoxic mechanisms involving cytokines may also play a role in host defense against chlamydiae. Interferon has been shown to inhibit intracellular growth of both C. trachomatis and C. psittaci in vitro. Further studies are needed on the role of T lymphocytes or lymphokines and macrophages in limiting the growth of C. trachomatis in conjunctival epithelial cells (the most appropriate target cells) and in exerting a toxic effect on these cells. The evidence suggests that macrophages are activated during C. trachomatis infection; this activation may lead to the release of monokines (such as interleukin 1) that may be important in the pathogenesis of scarring due to over-stimulation of cellular immunity during ocular infection. Cell-mediated immunity to ocular infection with C. trachomatis may thus be a double-edged sword. |
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Authors:
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D M Williams; J Schachter |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Reviews of infectious diseases Volume: 7 ISSN: 0162-0886 ISO Abbreviation: Rev. Infect. Dis. Publication Date: 1985 Nov-Dec |
Date Detail:
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Created Date: 1986-01-22 Completed Date: 1986-01-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7905878 Medline TA: Rev Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 754-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chlamydia Infections / immunology* Chlamydia trachomatis / immunology Chlamydophila psittaci / immunology Cytotoxicity, Immunologic Eye / immunology Guinea Pigs Hypersensitivity, Delayed / immunology Immunity, Cellular Lymphocytes / immunology Macrophages / immunology Mice Pneumonia / immunology Trachoma / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI-17981/AI/NIAID NIH HHS; EY-01205/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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