| Role of cell cycle regulators in lung carcinogenesis. | |
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MedLine Citation:
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PMID: 20139697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cellular division is an ordered, tightly regulated process involving multiple checkpoints that assess extracellular growth signals, cell size and DNA integrity. Progression throughout the cell cycle is based on the activation of different CDK-cyclin complexes that prevent cells from entering into a new phase until thay have successfully complete the previous one. In addition, a series of cell cycle checkpoints are designed to preserve genome integrity and chromosomal stability. Neoplastic lung cells develop the ability to bypass several of these checkpoints, and tumor cell proliferation is frequently associated with genetic or epigenetic alterations in key regulators of the cell cycle. The goal of this review is to summarize the knowledge about the dysregulation of major cell cycle regulators in lung cancer pathogenesis and to discuss the use of these proteins as targets for therapeutic intervention. |
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Authors:
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Beatrice Eymin; Sylvie Gazzeri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-01-16 |
Journal Detail:
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Title: Cell adhesion & migration Volume: 4 ISSN: 1933-6926 ISO Abbreviation: Cell Adh Migr Publication Date: 2010 Jan-Mar |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-09-09 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 101469464 Medline TA: Cell Adh Migr Country: United States |
Other Details:
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Languages: eng Pagination: 114-23 Citation Subset: IM |
Affiliation:
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Equipe Bases Moléculaires de la Progression des Cancers du Poumon, Centre de Recherche INSERM U823, Institut Albert Bonniot, Grenoble, France; Université Joseph Fourier, Grenoble, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Cycle Cell Cycle Proteins / metabolism* Humans Lung Neoplasms / metabolism*, pathology, therapy Models, Biological Precancerous Conditions / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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