Document Detail

Role of cell cycle proteins in CNS injury.
MedLine Citation:
PMID:  17404835     Owner:  NLM     Status:  MEDLINE    
Following trauma or ischemia to the central nervous system (CNS), there is a marked increase in the expression of cell cycle-related proteins. This up-regulation is associated with apoptosis of post-mitotic cells, including neurons and oligodendrocytes, both in vitro and in vivo. Cell cycle activation also induces proliferation of astrocytes and microglia, contributing to the glial scar and microglial activation with release of inflammatory factors. Treatment with cell cycle inhibitors in CNS injury models inhibits glial scar formation and neuronal cell death, resulting in substantially decreased lesion volumes and improved behavioral recovery. Here we critically review the role of cell cycle pathways in the pathophysiology of experimental stroke, traumatic brain injury and spinal cord injury, and discuss the potential of cell cycle inhibitors as neuroprotective agents.
Kimberly R Byrnes; Alan I Faden
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-04-03
Journal Detail:
Title:  Neurochemical research     Volume:  32     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-18     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1799-807     Citation Subset:  IM    
Department of Neuroscience, Georgetown University Medical Center, Room EP16A, New Research Building, 3970 Reservoir Rd., NW, Washington, DC 20057, USA.
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MeSH Terms
Astrocytes / drug effects
Cell Cycle / drug effects,  physiology
Cell Cycle Proteins / chemistry,  pharmacology,  physiology*
Central Nervous System / injuries*,  physiopathology*
Central Nervous System Diseases / physiopathology*
Microglia / drug effects
Neuroprotective Agents*
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Neuroprotective Agents

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