Document Detail


Role of caudal in hindgut specification and gastrulation suggests homology between Drosophila amnioproctodeal invagination and vertebrate blastopore.
MedLine Citation:
PMID:  9609826     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During early embryogenesis in Drosophila, caudal mRNA is distributed as a gradient with its highest level at the posterior of the embryo. This suggests that the Caudal homeodomain transcription factor might play a role in establishing the posterior domains of the embryo that undergo gastrulation and give rise to the posterior gut. By generating embryos lacking both the maternal and zygotic mRNA contribution, we show that caudal is essential for invagination of the hindgut primordium and for further specification and development of the hindgut. These effects are achieved by the function of caudal in activating different target genes, namely folded gastrulation, which is required for invagination of the posterior gut primordium, and fork head and wingless, which are required to promote development of the internalized hindgut primordium. caudal is not sufficient for hindgut gastrulation and development, however, as it does not play a significant role in activating expression of the genes tailless, huckebein, brachyenteron and bowel. We argue that caudal and other genes expressed at the posterior of the Drosophila embryo (fork head, brachyenteron and wingless) constitute a conserved constellation of genes that plays a required role in gastrulation and gut development.
Authors:
L H Wu; J A Lengyel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  125     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-08-06     Completed Date:  1998-08-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2433-42     Citation Subset:  IM    
Affiliation:
Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA 90095-1606, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning*
Crosses, Genetic
Drosophila Proteins
Drosophila melanogaster
Embryo, Nonmammalian / physiology*
Embryonic Induction
Female
Gastrula / physiology*
Gene Expression Regulation, Developmental
Homeodomain Proteins / biosynthesis,  physiology*
Homozygote
Intestines / embryology*
Male
Morphogenesis
Transcription Factors
Vertebrates / physiology
Zygote / physiology
Grant Support
ID/Acronym/Agency:
GM 51270/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins; 0/Homeodomain Proteins; 0/Transcription Factors; 0/caudal protein, Drosophila

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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