Document Detail


Role of cardiopulmonary and carotid sinus baroreceptors in regulating renal sympathetic nerve activity during water immersion in conscious dogs.
MedLine Citation:
PMID:  19369587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to investigate how loading of cardiopulmonary baroreceptors induced by water immersion (WI) modifies baroreflex control of renal sympathetic nerve activity (RSNA) in conscious dogs. Nine dogs were chronically instrumented for measuring carotid sinus nerve activity (CSNA), RSNA, carotid arterial (Pca), and central venous (Pcv) pressures. The stimulus-response relationships of Pca-CSNA and Pca-RSNA were determined simultaneously in the same dog by changing Pca using rapid intravenous infusions vasoactive drugs during pre-WI and WI. WI increased central venous pressure significantly (P < 0.05) by 10.4 mmHg. WI shifted the Pca-RSNA curve acutely leftward compared with the pre-WI period, which was associated with significant (P < 0.05) decreases in the saturation pressure by 39.0 mmHg and operating range by 43.1 mmHg. WI relocated the operating pressure to near the saturation pressure, where the gain was low. The Pca-CSNA curve obtained during WI was identical to that obtained during pre-WI period. These results suggest that the shift in baroreflex control of RSNA could be attributed to the inhibitory influence of the cardiopulmonary mechanoreceptor loading and not by the resetting of carotid baroreceptors per se.
Authors:
Kenju Miki; Misa Yoshimoto; Yoshiaki Hayashida; Keizo Shiraki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-15
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  296     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-21     Completed Date:  2009-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1807-12     Citation Subset:  IM    
Affiliation:
Department of Environmental Health, Life Science and Human Technology, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan. k.miki@cc.nara-wu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Baroreflex* / drug effects
Blood Pressure* / drug effects
Carotid Sinus / innervation*
Central Venous Pressure
Consciousness*
Dogs
Female
Homeostasis
Immersion*
Infusions, Intravenous
Kidney / innervation*
Mechanoreceptors / physiology*
Sympathetic Nervous System / drug effects,  physiology*
Vasoconstrictor Agents / administration & dosage
Vasodilator Agents / administration & dosage
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 0/Vasodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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