Document Detail

Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biology.
MedLine Citation:
PMID:  21960726     Owner:  NLM     Status:  MEDLINE    
For nearly a century, the human heart has been viewed as a terminally differentiated postmitotic organ in which the number of cardiomyocytes is established at birth, and these cells persist throughout the lifespan of the organ and organism. However, the discovery that cardiac stem cells live in the heart and differentiate into the various cardiac cell lineages has changed profoundly our understanding of myocardial biology. Cardiac stem cells regulate myocyte turnover and condition myocardial recovery after injury. This novel information imposes a reconsideration of the mechanisms involved in myocardial aging and the progression of cardiac hypertrophy to heart failure. Similarly, the processes implicated in the adaptation of the infarcted heart have to be dissected in terms of the critical role that cardiac stem cells and myocyte regeneration play in the restoration of myocardial mass and ventricular function. Several categories of cardiac progenitors have been described but, thus far, the c-kit-positive cell is the only class of resident cells with the biological and functional properties of tissue specific adult stem cells.
Annarosa Leri; Jan Kajstura; Piero Anversa
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Circulation research     Volume:  109     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-30     Completed Date:  2011-11-15     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  941-61     Citation Subset:  IM    
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MeSH Terms
Adult Stem Cells / cytology,  physiology
Cell Differentiation / physiology
Cell Enlargement
Heart Diseases / physiopathology*
Myocardium / cytology*
Myocytes, Cardiac / cytology,  physiology*
Stem Cells / cytology,  physiology*
Grant Support
P01 HL092868/HL/NHLBI NIH HHS; P01 HL092868-04/HL/NHLBI NIH HHS; R01 AG017042/AG/NIA NIH HHS; R01 AG017042-05/AG/NIA NIH HHS; R01 AG017042-10/AG/NIA NIH HHS; R01 AG026107/AG/NIA NIH HHS; R01 AG026107-05/AG/NIA NIH HHS; R01 AG037490/AG/NIA NIH HHS; R01 AG037490-01/AG/NIA NIH HHS; R01 AG037495/AG/NIA NIH HHS; R01 AG037495-02/AG/NIA NIH HHS; R01 HL039902/HL/NHLBI NIH HHS; R01 HL039902-17/HL/NHLBI NIH HHS; R01 HL065573/HL/NHLBI NIH HHS; R01 HL065573-04/HL/NHLBI NIH HHS; R01 HL065577/HL/NHLBI NIH HHS; R01 HL065577-06/HL/NHLBI NIH HHS; R01 HL075480/HL/NHLBI NIH HHS; R01 HL075480-04/HL/NHLBI NIH HHS; R01 HL105532/HL/NHLBI NIH HHS; R01 HL105532-01/HL/NHLBI NIH HHS; R01 HL111183/HL/NHLBI NIH HHS; R01 HL111183-02/HL/NHLBI NIH HHS; R01 HL114346/HL/NHLBI NIH HHS; R01 HL114346-01/HL/NHLBI NIH HHS; R37 HL081737/HL/NHLBI NIH HHS; R37 HL081737-01/HL/NHLBI NIH HHS
Comment In:
Circ Res. 2012 Jan 6;110(1):e17-8; author reply e19-21   [PMID:  22223215 ]

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