| Role of carbon-11 choline PET/CT in the management of uterine carcinoma: initial experience. | |
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MedLine Citation:
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PMID: 19333688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The present study was conducted to clarify the role of carbon-11 choline ((11)C-choline) positron emission tomography (PET)/computed tomography (CT) in the management of uterine carcinoma. MATERIALS AND METHODS: Twenty-two patients who underwent (11)C-choline PET/CT and pelvic MRI were evaluated retrospectively. The images were reviewed by a board-certified radiologist and a nuclear medicine specialist who were unaware of any clinical information, and a consensus was reached. Diagnostic accuracy of PET/CT was evaluated for staging. The reference standard consisted of histological examination (n = 17) and follow-up conventional CT (n = 5). In five patients with cervical carcinoma, (11)C-choline PET/CT was performed before and after treatment that consisted of cisplatin infusion and subsequent radiotherapy. Standardized uptake value (SUV) was compared with uni-dimensional and volumetric measurements that were made on magnetic resonance images (MRI) before and after treatment. RESULTS: Based on PET/CT interpretations, the reviewers correctly classified T stage in 8 patients (47%), N stage in 21 patients (96%), M stage in 20 patients (91%), and TNM stage in 15 patients (88%). Tumor size, volume, and SUV decreased after treatment in five patients with cervical carcinoma. Using the Pearson correlation test, a significant correlation was found between the reduction rate of SUV and reduction rate of tumor volume. CONCLUSIONS: (11)C-choline PET/CT is an accurate means for the management of patients with uterine carcinoma. The combination of (11)C-choline PET/CT and MRI increases the accuracy of staging in patients with uterine carcinoma. |
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Authors:
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Keitaro Sofue; Ukihide Tateishi; Morio Sawada; Tetsuo Maeda; Takashi Terauchi; Daisuke Kano; Yasuaki Arai; Tomio Inoue; Kazuro Sugimura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-31 |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 23 ISSN: 0914-7187 ISO Abbreviation: Ann Nucl Med Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-13 Completed Date: 2009-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 235-43 Citation Subset: IM |
Affiliation:
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Division of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carbon Radioisotopes Choline / chemistry*, diagnostic use* Female Humans Magnetic Resonance Imaging Middle Aged Neoplasm Staging Positron-Emission Tomography Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed Uterine Neoplasms / pathology, radiography*, radionuclide imaging*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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