Document Detail

Role of caloric restriction in the prolongation of life.
MedLine Citation:
PMID:  8556686     Owner:  NLM     Status:  MEDLINE    
Restriction of caloric intake increases longevity, slows the rate of functional decline, and reduces incidence of age-related disease in a variety of species. Most laboratory rodent studies have initiated restriction before puberty, whereas ongoing studies in nonhuman primates utilize restriction in adulthood. The mechanism of action of caloric restriction remains unknown; however, data suggest that cellular functions are altered in such a way that destructive by-products of metabolism are reduced, and defense or repair systems are enhanced by this nutritional manipulation.
R J McCarter
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Clinics in geriatric medicine     Volume:  11     ISSN:  0749-0690     ISO Abbreviation:  Clin. Geriatr. Med.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-02-28     Completed Date:  1996-02-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8603766     Medline TA:  Clin Geriatr Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  553-65     Citation Subset:  IM    
Department of Physiology, University of Texas Health Science Center, San Antonio, USA.
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MeSH Terms
Aging / physiology
Cohort Studies
Diet, Reducing
Energy Intake / physiology*
Longevity / physiology*
Survival Analysis
Grant Support

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