| Role of caloric homeostasis and reward in alcohol intake in Syrian golden hamsters. | |
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MedLine Citation:
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PMID: 20688091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Syrian golden hamster drinks alcohol readily, but only achieves moderate blood alcohol levels, and does not go through withdrawal from alcohol. Because the hamster is a model of caloric homeostasis, both caloric content and reward value may contribute to the hamster's alcohol consumption. The current study examines alcohol consumption in the hamster when a caloric or non-caloric sweet solution is concurrently available and caloric intake in the hamster before, during, and after exposure to either: alcohol, sucrose or saccharin. In Experiments 1 and 2, hamsters were given access to alcohol (15% v/v) and water; once alcohol consumption steadied, a bottle containing an ascending concentration of sucrose (99-614 mM) or saccharin (2-10 mM), or water was added. In Experiment 3, hamsters were given access to alcohol (15% v/v), sucrose (614 mM), saccharin (4 mM), or a second water bottle for 14 days. After the second bottle was removed, measurements continued for 14days. Sucrose exposure suppressed alcohol consumption at concentrations lower in calories than the alcohol solution. Saccharin exposure failed to suppress alcohol consumption. Exposure to sucrose and alcohol but not saccharin decreased food intake. Decreased alcohol consumption in response to a caloric sweetener and decreased food intake during alcohol exposure support that alcohol consumption by the hamster is mediated by caloric content. However, suppression of alcohol intake by a sucrose solution of lower caloric content and the equivalent intake of individual alcohol, sucrose and saccharin solutions support a role for reward value in alcohol consumption. |
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Authors:
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Danielle Gulick; Alan I Green |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-03 |
Journal Detail:
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Title: Physiology & behavior Volume: 101 ISSN: 1873-507X ISO Abbreviation: Physiol. Behav. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-28 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 518-26 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Neuroscience Center, Dartmouth Medical School, Lebanon, NH 03756, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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metabolism*,
prevention & control Animals Appetite Regulation / physiology* Calorimetry Choice Behavior / drug effects, physiology* Cricetinae Dose-Response Relationship, Drug Energy Intake / drug effects, physiology* Homeostasis Male Mesocricetus Reward Saccharin / pharmacology Sucrose / metabolism*, pharmacology Sweetening Agents / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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1R03AA014644/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Sweetening Agents; 57-50-1/Sucrose; 81-07-2/Saccharin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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