| Role of calcium malabsorption in the development of secondary hyperparathyroidism after biliopancreatic diversion. | |
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MedLine Citation:
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PMID: 19092286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Secondary hyperparathyroidism (SH) is a frequent metabolic complication of bariatric surgery. Around 70%of patients who undergo biliopancreatic diversion (BPD) have this complication in the long term. The aim of this study was to evaluate the relative influence of vitamin D deficiency and calcium malabsorption in the development of SH in patients who underwent BPD. We reviewed the mean values of PTH throughout the post-operative follow-up and of related biochemical data (25-hydroxyvitamin D, calcium, magnesium) of 121 patients who underwent BPD at our institute from November 1996 to November 2004 (mean follow-up 66 months). Mean PTH correlated negatively with mean 25-hydroxyvitamin D (r=-0.27, p=0.003) and with urinary calcium(r=-0.19, p=0.047), and positively with age (r=0.22, p=0.018). However, a high mean PTH was found in 48.7% patients with mean 25-hydroxyvitamin D >or=30 ng/ml and in 80.0% patients with mean 25-hydroxyvitamin D between 20 and 30 ng/ml. The mean PTH was normal in 5 patients without calcium supplements at present, and progressively increased in parallel to the calcium dose in the rest of patients, although mean 25-hydroxyvitamin D levels were not related to the calcium dose. Our data suggest that individual differences in active and/or passive calcium absorption determine intractable SH after BPD in around half of the patients who have normal levels of 25-hydroxyvitamin D and in 80% of patients with 25-hydroxyvitamin D levels between 20 and 30 ng/ml after BPD, worsening with age. |
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Authors:
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J A Balsa; J I Botella-Carretero; R Peromingo; I Zamarrón; F Arrieta; T Muñoz-Malo; C Vázquez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 31 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-12-18 Completed Date: 2009-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: 845-50 Citation Subset: IM |
Affiliation:
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Department of Endocrinology and Clinical Nutrition, Ramón y Cajal Hospital, Madrid, Spain. jbalsa.hrc@salud.madrid.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bariatric Surgery / adverse effects Biliopancreatic Diversion / adverse effects* Calcium / metabolism*, urine Female Humans Hyperparathyroidism, Secondary / etiology* Magnesium / blood Malabsorption Syndromes / complications* Male Menopause Middle Aged Obesity, Morbid / surgery Parathyroid Hormone / metabolism Sex Factors Vitamin D / analogs & derivatives, blood Vitamin D Deficiency / complications* |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; 7439-95-4/Magnesium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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