| Role of calcium ions in the pressure control of renin secretion from the kidneys. | |
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MedLine Citation:
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PMID: 7971174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study we examined the role of calcium ions in the control of renin release by the renal artery pressure. For this purpose renin secretion rates (RSR) were measured in isolated rat kidneys perfused at pressures of 140, 100, 80 and 40 mmHg (19, 13, 11, 5 kPa) with media containing either 1.5 mmol/l ("normal") or zero calcium concentrations (calcium-free perfusate with 0.5 mmol/l EGTA). At normal calcium the RSR was inversely related to the renal artery pressure, whereas calcium withdrawal resulted in an almost linear and proportional relationship between RSR and perfusion pressure. As a consequence, RSR at 140 mm Hg (19 kPa) with a calcium-free medium was similar to renin release at 40 mm Hg (5 kPa) with normal calcium. The nitric oxide (NO) donor sodium nitroprusside (1 mumol/l) stimulated RSR in a pressure-dependent fashion at a calcium concentration of 1.5 mmol/l. With a calcium-free perfusate, sodium nitroprusside did not restore the inverse pressure dependence of RSR seen with normal calcium but almost doubled the RSR across the whole pressure range. Whilst RSR was significantly reduced by angiotensin II (1 nmol/l) in the range between 40 mmHg and 140 mmHg (5-19 kPa) with normal calcium, withdrawal of extracellular calcium ions practically abolished the inhibitory action of angiotensin II. Since angiotensin II attenuated RSR especially at low renal perfusion pressure, our results indicate that renin release in this pressure range is still inhibitable by calcium mobilization in renal juxtaglomerular cells. Thus, the enhancement of renin secretion at lower pressures cannot be explained by a decreased sensitivity of renin release towards calcium ions.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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H Scholz; M Hamann; K H Götz; A Kurtz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 428 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-12-22 Completed Date: 1994-12-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: GERMANY |
Other Details:
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Languages: eng Pagination: 173-8 Citation Subset: IM |
Affiliation:
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Institut für Physiologie I, Universität Regensburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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pharmacology* Animals Blood Pressure Calcium / metabolism, physiology* Juxtaglomerular Apparatus / cytology, drug effects, metabolism Kidney / blood supply, drug effects, secretion* Male Muscle, Smooth, Vascular / drug effects Nitroprusside / pharmacology Perfusion Pressoreceptors / drug effects, physiology* Rats Rats, Sprague-Dawley Renal Artery / physiology Renin / secretion* Vasoconstriction / drug effects |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 15078-28-1/Nitroprusside; 7440-70-2/Calcium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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