Document Detail

Role of calcium ions in the pressure control of renin secretion from the kidneys.
MedLine Citation:
PMID:  7971174     Owner:  NLM     Status:  MEDLINE    
In this study we examined the role of calcium ions in the control of renin release by the renal artery pressure. For this purpose renin secretion rates (RSR) were measured in isolated rat kidneys perfused at pressures of 140, 100, 80 and 40 mmHg (19, 13, 11, 5 kPa) with media containing either 1.5 mmol/l ("normal") or zero calcium concentrations (calcium-free perfusate with 0.5 mmol/l EGTA). At normal calcium the RSR was inversely related to the renal artery pressure, whereas calcium withdrawal resulted in an almost linear and proportional relationship between RSR and perfusion pressure. As a consequence, RSR at 140 mm Hg (19 kPa) with a calcium-free medium was similar to renin release at 40 mm Hg (5 kPa) with normal calcium. The nitric oxide (NO) donor sodium nitroprusside (1 mumol/l) stimulated RSR in a pressure-dependent fashion at a calcium concentration of 1.5 mmol/l. With a calcium-free perfusate, sodium nitroprusside did not restore the inverse pressure dependence of RSR seen with normal calcium but almost doubled the RSR across the whole pressure range. Whilst RSR was significantly reduced by angiotensin II (1 nmol/l) in the range between 40 mmHg and 140 mmHg (5-19 kPa) with normal calcium, withdrawal of extracellular calcium ions practically abolished the inhibitory action of angiotensin II. Since angiotensin II attenuated RSR especially at low renal perfusion pressure, our results indicate that renin release in this pressure range is still inhibitable by calcium mobilization in renal juxtaglomerular cells. Thus, the enhancement of renin secretion at lower pressures cannot be explained by a decreased sensitivity of renin release towards calcium ions.(ABSTRACT TRUNCATED AT 250 WORDS)
H Scholz; M Hamann; K H Götz; A Kurtz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  428     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-12-22     Completed Date:  1994-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM    
Institut für Physiologie I, Universität Regensburg, Germany.
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MeSH Terms
Angiotensin II / pharmacology*
Blood Pressure
Calcium / metabolism,  physiology*
Juxtaglomerular Apparatus / cytology,  drug effects,  metabolism
Kidney / blood supply,  drug effects,  secretion*
Muscle, Smooth, Vascular / drug effects
Nitroprusside / pharmacology
Pressoreceptors / drug effects,  physiology*
Rats, Sprague-Dawley
Renal Artery / physiology
Renin / secretion*
Vasoconstriction / drug effects
Reg. No./Substance:
11128-99-7/Angiotensin II; 15078-28-1/Nitroprusside; 7440-70-2/Calcium; EC

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