| Role of calcium channels in congenital heart block. | |
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MedLine Citation:
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PMID: 20696020 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congenital heart block (CHB) is a conduction abnormality that affects hearts of foetuses and/or newborn to mothers with autoantibodies reactive with the intracellular soluble ribonucleoproteins 48-kD La, 52-kD Ro and 60-kD Ro. CHB carries substantial mortality and morbidity, with more than 60% of affected children requiring lifelong pacemakers. Several hypotheses have been proposed to explain the pathogenesis of CHB. These can be grouped under three main hypotheses: Apoptosis, Serotoninergic and Ca channel hypothesis. Here, we discuss these hypotheses and provide recent scientific thinking that will most likely dominate the future of this field of research. |
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Authors:
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E Karnabi; M Boutjdir |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Scandinavian journal of immunology Volume: 72 ISSN: 1365-3083 ISO Abbreviation: Scand. J. Immunol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-10 Completed Date: 2010-10-21 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 0323767 Medline TA: Scand J Immunol Country: England |
Other Details:
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Languages: eng Pagination: 226-34 Citation Subset: IM |
Affiliation:
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VA New York Harbor Healthcare System, New York, NY, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / immunology Autoantibodies / immunology Calcium Channels, L-Type / immunology*, metabolism* Female Heart Block / congenital*, etiology*, immunology*, pathology Humans Infant, Newborn Infant, Newborn, Diseases / etiology*, immunology, metabolism*, pathology Maternal-Fetal Exchange / immunology Models, Biological* Pregnancy Receptors, Serotonin, 5-HT4 / immunology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL077494-04/HL/NHLBI NIH HHS; R01-HL-077494/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Calcium Channels, L-Type; 158165-40-3/Receptors, Serotonin, 5-HT4 |
| Comments/Corrections | |
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