Document Detail


Role of bursin in the development of B lymphocytes in chicken embryonic Bursa of Fabricius.
MedLine Citation:
PMID:  11356228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Localization and role of bursin during Bursa of Fabricius (BF) ontogeny were examined by immunohistochemical staining and by in ovo injection with anti-bursin antibody. Mouse monoclonal anti-bursin antibody HU2 was generated by immunization with synthetic bursin. It recognized reticular cells (REC), follicular associated epithelium (FAE), FAE-supporting cells, and the basal layer of interfollicular epithelium (IFE) in the mature BF. Bu-1(+) cells were first detectable in the mesenchyme area at 13 days of embryogenesis (E13) before bud formation, then lined up along the bud, and homed into the bud at around E15. IgM(+) cells were detected in the bud after E13. Bursin was first observed at the under edge of the bud. Injection of HU2 into embryonal vein at E13 suppressed the appearance of IgM(+) cells in the Bursa at E17. These results indicate that bursin exists beneath the bud and may act on the appearance of IgM(+) cells during BF ontogeny.
Authors:
Y Otsubo; N Chen; E Kajiwara; H Horiuchi; H Matsuda; S Furusawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental and comparative immunology     Volume:  25     ISSN:  0145-305X     ISO Abbreviation:  Dev. Comp. Immunol.     Publication Date:    2001 Jun-Jul
Date Detail:
Created Date:  2001-05-17     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708205     Medline TA:  Dev Comp Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  485-93     Citation Subset:  IM    
Affiliation:
Department of Immunobiology, Faculty of Applied Biological Science, Hiroshima University, 1-4-4 Kagamiyama, Higashi-Hiroshima, 739-8528, Hiroshima, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / immunology
Antibody Specificity
B-Lymphocytes / cytology*
Bursa of Fabricius / embryology*
Cell Differentiation
Chick Embryo
Female
Mice
Mice, Inbred BALB C
Oligopeptides / immunology,  physiology*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Oligopeptides; 60267-34-7/bursopoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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