| Role of bombesin on gut mucosal growth. | |
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MedLine Citation:
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PMID: 7618976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The authors examined the effects of exogenous bombesin (BBS) on gut mucosal growth in chow-fed rats and the mucosal regeneration after gut atrophy brought about by feeding an elemental diet and after intestinal injury produced by methotrexate (MTX). SUMMARY BACKGROUND DATA: Bombesin is one of many gastrointestinal peptides implicated in the regulation of gut mucosal growth. Although BBS is known to stimulate growth of normal pancreatic tissue, the trophic effect of BBS on gut mucosa is less clear and its exact role in gut mucosal regeneration and repair is not known. METHODS: Rats were fed a regular chow diet (control) or an elemental diet plus either saline or BBS (10 micrograms/kg). In another experiment, rats fed a chow diet and treated with saline or BBS were given MTX (20 micrograms/kg) or a single intraperitoneal injection. In all experiments, small and large bowel mucosa and pancreas were removed and analyzed for BBS-mediated proliferation. RESULTS: Bombesin produced significant mucosal proliferation of the small bowel at day 14, but not at day 7, in rats fed regular chow. In contrast, BBS treatment for 7 days produced significant proliferation in both the atrophic and injured gut mucosa of rats given elemental diet or MTX. CONCLUSIONS: Bombesin may be an important enterotrophic factor for normal mucosal proliferation and may be clinically beneficial as an agent to restore or maintain gut mucosa during periods of atrophy or injury. |
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Authors:
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K U Chu; B M Evers; J Ishizuka; C M Townsend; J C Thompson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of surgery Volume: 222 ISSN: 0003-4932 ISO Abbreviation: Ann. Surg. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1995-08-18 Completed Date: 1995-08-18 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372354 Medline TA: Ann Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 94-100 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, University of Texas Medical Branch, Galveston, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrophy Bombesin / pharmacology* Diet Intestinal Diseases / chemically induced Intestinal Mucosa / drug effects*, growth & development*, pathology Male Methotrexate / administration & dosage Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
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31362-50-2/Bombesin; 59-05-2/Methotrexate |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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