Document Detail


Role of bile acids in the pathogenesis of aspirin-induced gastric mucosal hemorrhage in rats.
MedLine Citation:
PMID:  1078804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The simultaneous oral administration of acetylsalicylic acid (64 mg per kg) and taurocholic acid (2.5 mM) to rats induced gastric hemorrhagic mucosal bleeding in 82.4% of animals compared with 29.7% of animals given acetylsalicylic acid alone. Taurodeoxycholic acid and glycocholic acid with acetylsalicylic acid also significantly increased the incidence of gastric hemorrhagic mucosal bleeding compared with the control animals, but cholic acid, chenodeoxycholic acid, and deoxycholic acid did not have a significant effect. Hemorrhagic mucosal lesions were not observed when the bile acids studied were administered alone. These results indicate a possible role for certain bile acids in the pathogenesis of gastric mucosal bleeding after the ingestion of aspirin.
Authors:
P F Semple; R I Russell
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  68     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-06-02     Completed Date:  1975-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-70     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Aspirin / administration & dosage,  adverse effects*
Bile Acids and Salts / pharmacology*
Chenodeoxycholic Acid / administration & dosage,  pharmacology
Cholic Acids / administration & dosage,  pharmacology
Drug Synergism
Gastric Mucosa / drug effects*
Gastrointestinal Hemorrhage / chemically induced*,  epidemiology
Glycocholic Acid / administration & dosage,  pharmacology
Male
Rats
Taurocholic Acid / administration & dosage,  analogs & derivatives,  pharmacology
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholic Acids; 474-25-9/Chenodeoxycholic Acid; 475-31-0/Glycocholic Acid; 50-78-2/Aspirin; 81-24-3/Taurocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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