| Role of bile acids in the pathogenesis of aspirin-induced gastric mucosal hemorrhage in rats. | |
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MedLine Citation:
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PMID: 1078804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The simultaneous oral administration of acetylsalicylic acid (64 mg per kg) and taurocholic acid (2.5 mM) to rats induced gastric hemorrhagic mucosal bleeding in 82.4% of animals compared with 29.7% of animals given acetylsalicylic acid alone. Taurodeoxycholic acid and glycocholic acid with acetylsalicylic acid also significantly increased the incidence of gastric hemorrhagic mucosal bleeding compared with the control animals, but cholic acid, chenodeoxycholic acid, and deoxycholic acid did not have a significant effect. Hemorrhagic mucosal lesions were not observed when the bile acids studied were administered alone. These results indicate a possible role for certain bile acids in the pathogenesis of gastric mucosal bleeding after the ingestion of aspirin. |
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Authors:
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P F Semple; R I Russell |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 68 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-06-02 Completed Date: 1975-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 67-70 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Aspirin / administration & dosage, adverse effects* Bile Acids and Salts / pharmacology* Chenodeoxycholic Acid / administration & dosage, pharmacology Cholic Acids / administration & dosage, pharmacology Drug Synergism Gastric Mucosa / drug effects* Gastrointestinal Hemorrhage / chemically induced*, epidemiology Glycocholic Acid / administration & dosage, pharmacology Male Rats Taurocholic Acid / administration & dosage, analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Cholic Acids; 474-25-9/Chenodeoxycholic Acid; 475-31-0/Glycocholic Acid; 50-78-2/Aspirin; 81-24-3/Taurocholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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