| Role of beta3 integrin in acute renal allograft rejection in humans. | |
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MedLine Citation:
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PMID: 17928472 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Beta3 Integrin may play a role in the process of acute rejection by increasing leukocyte adhesion to the endothelium, cytotoxic T lymphocyte activation, and platelet aggregation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: For investigation of the role of beta3 integrin in the pathogenesis of acute rejection, this study examined the surface expression of beta3 integrin on leukocyte subsets and analyzed a common single-nucleotide polymorphism in exon 2 of the gene encoding the beta3 subunit that generates two beta3 integrin isoforms, termed Pl(A1) and Pl(A2). Pl(A) genotype was determined in blood samples from 445 renal allograft recipients at two centers. Patients were then grouped by Pl(A) genotype, and clinical outcomes as recorded in a preexisting database were analyzed. RESULTS: Although almost all monocytes express beta3 integrin, its expression was also found on all leukocyte subsets, including T, B, and NK cells. The percentage of patients who experienced acute rejection was noted to be significantly higher in those with Pl(A1)/Pl(A1) (TT) genotype versus patients with the Pl(A1)/Pl(A2) or Pl(A2)/Pl(A2) (CT or CC) genotypes (33% for TT versus 20% for CT or CC). In a multivariate analysis, the Pl(A1)/Pl(A1) (TT) genotype remained significantly associated with acute rejection. Patients with Pl(A1)/Pl(A1) (TT) genotype also exhibited a higher number of acute rejection episodes per patient. CONCLUSIONS: The Pl(A1)/Pl(A1) (TT) genotype is associated with an increased incidence of acute renal allograft rejection in humans, supporting a role for beta3 integrin in the pathophysiology of acute rejection. |
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Authors:
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Arun Chandrakantan; David H McDermott; Huong Thi Bich Tran; Mollie Jurewicz; Lorenzo Gallon; Robert Gaston; Edgar Milford; Reza Abdi |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2007-10-10 |
Journal Detail:
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Title: Clinical journal of the American Society of Nephrology : CJASN Volume: 2 ISSN: 1555-905X ISO Abbreviation: - Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-26 Completed Date: 2007-11-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101271570 Medline TA: Clin J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 1268-73 Citation Subset: IM |
Affiliation:
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Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult African Continental Ancestry Group Aged Cross-Sectional Studies European Continental Ancestry Group Female Genotype Graft Rejection / ethnology, etiology*, genetics Histocompatibility Testing Humans Integrin beta3 / blood, genetics, physiology* Kidney Transplantation / adverse effects* Male Middle Aged Polymorphism, Genetic Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Integrin beta3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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