Document Detail


Role of beta3 integrin in acute renal allograft rejection in humans.
MedLine Citation:
PMID:  17928472     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: Beta3 Integrin may play a role in the process of acute rejection by increasing leukocyte adhesion to the endothelium, cytotoxic T lymphocyte activation, and platelet aggregation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: For investigation of the role of beta3 integrin in the pathogenesis of acute rejection, this study examined the surface expression of beta3 integrin on leukocyte subsets and analyzed a common single-nucleotide polymorphism in exon 2 of the gene encoding the beta3 subunit that generates two beta3 integrin isoforms, termed Pl(A1) and Pl(A2). Pl(A) genotype was determined in blood samples from 445 renal allograft recipients at two centers. Patients were then grouped by Pl(A) genotype, and clinical outcomes as recorded in a preexisting database were analyzed. RESULTS: Although almost all monocytes express beta3 integrin, its expression was also found on all leukocyte subsets, including T, B, and NK cells. The percentage of patients who experienced acute rejection was noted to be significantly higher in those with Pl(A1)/Pl(A1) (TT) genotype versus patients with the Pl(A1)/Pl(A2) or Pl(A2)/Pl(A2) (CT or CC) genotypes (33% for TT versus 20% for CT or CC). In a multivariate analysis, the Pl(A1)/Pl(A1) (TT) genotype remained significantly associated with acute rejection. Patients with Pl(A1)/Pl(A1) (TT) genotype also exhibited a higher number of acute rejection episodes per patient. CONCLUSIONS: The Pl(A1)/Pl(A1) (TT) genotype is associated with an increased incidence of acute renal allograft rejection in humans, supporting a role for beta3 integrin in the pathophysiology of acute rejection.
Authors:
Arun Chandrakantan; David H McDermott; Huong Thi Bich Tran; Mollie Jurewicz; Lorenzo Gallon; Robert Gaston; Edgar Milford; Reza Abdi
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2007-10-10
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  2     ISSN:  1555-905X     ISO Abbreviation:  -     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-26     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1268-73     Citation Subset:  IM    
Affiliation:
Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
African Continental Ancestry Group
Aged
Cross-Sectional Studies
European Continental Ancestry Group
Female
Genotype
Graft Rejection / ethnology,  etiology*,  genetics
Histocompatibility Testing
Humans
Integrin beta3 / blood,  genetics,  physiology*
Kidney Transplantation / adverse effects*
Male
Middle Aged
Polymorphism, Genetic
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Integrin beta3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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