Document Detail


Role of beta-adrenergic mechanisms in exercise training-induced metabolic changes in respiratory and locomotor muscle.
MedLine Citation:
PMID:  7713624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To test the hypothesis that beta-adrenergic stimulation is required for the normal increase in oxidative capacity of respiratory and locomotor skeletal muscle in response to exercise training, we examined the effects of beta-blockade on muscle oxidative capacity in trained and sedentary rats. Thirty-four female adult Sprague-Dawley rats were randomly divided into four experimental groups: 1) trained+propranolol (TP); 2) trained + sham injection (TS); 3) sedentary + propranolol (SP); and 4) sedentary + sham injection (SS). Training increased (p < 0.05) citrate synthase (CS) activity in the plantaris (+29%) and costal diaphragm (+12%) of TS animals compared to SS animals. In contrast, training did not (p > 0.05) increase costal diaphragm CS activity in TP animals compared to the SS group. Further, although training increased (p < 0.05) plantaris CS activity in the TP group (+18%) compared to the SP group, the training-induced increase in muscle CS activity was 11% lower (p < 0.05) than observed in TS animals. Collectively, these results suggest that beta-adrenergic mechanisms may play a role in the normal training-induced increase in oxidative capacity in both respiratory and locomotor skeletal muscles.
Authors:
S K Powers; M Wade; D Criswell; R A Herb; S Dodd; R Hussain; D Martin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of sports medicine     Volume:  16     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-16     Completed Date:  1995-05-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  13-8     Citation Subset:  IM; S    
Affiliation:
Department of Exercise and Sport Sciences, University of Florida, Gainesville, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology*
Animals
Female
Muscle Fibers, Skeletal / physiology
Muscle, Skeletal / chemistry,  physiology*
Myosins / analysis
Physical Conditioning, Animal / physiology*
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, beta / physiology*
Respiratory Muscles / chemistry,  physiology*
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, beta; EC 3.6.4.1/Myosins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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