Document Detail

Role of beta 1- and beta 2-adrenoceptor subtypes in preconditioning against myocardial dysfunction after ischemia and reperfusion.
MedLine Citation:
PMID:  12605018     Owner:  NLM     Status:  MEDLINE    
Using an isolated nonworking rat heart model, this study investigated the role of beta-adrenergic preconditioning (beta-PC) to attenuate myocardial dysfunction after an ischemia/reperfusion injury. After a 20-min stabilization period, the noradrenaline depleted hearts were perfused for 5 min with isoproterenol (ISO) before 40-min global ischemia (I) followed by 30-min reperfusion (R). ISO 0.02 microM provided significant protection versus unconditioned in vivo reserpinized IR control, causing a decrease of creatine kinase (CK) release (mIU/min/g wet weight) on reperfusion in coronary effluent, a preservation of the mean coronary flow (MCF) and preservation of left ventricular function assessed by the rate-pressure product (RPP). These beneficial effects were similar to those of ischemic preconditioning (I-PC) in both nonreserpinized and reserpinized rats. Propranolol (1 microM) and atenolol (10 microM) completely suppressed the ISO preconditioning. In contrast, ICI 118551 (2 microM) a highly selective beta -blocker, did not blunt the salutary effects of ISO on CK release and MCF preservation. These results indicate that ISO pretreatment provides a significant cardioprotection against prolonged ischemic myocardial injury. Although endogenous catecholamines are not necessary for I-PC in isolated rat hearts, cardioprotection provided by beta-adrenergic stimulation is quite similar to I-PC. This significant cardioprotection is mediated less by beta -adrenoceptor than by beta -adrenoceptor activation, which seems to play a crucial role in the beta-PC mechanism.
Carole Frances; Pierre Nazeyrollas; Alain Prevost; Françoise Moreau; Jean Pisani; Siamak Davani; Jean-Pierre Kantelip; Hervé Millart
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  41     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-02-26     Completed Date:  2003-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  396-405     Citation Subset:  IM    
Department of Pharmacology, Reims University Hospital, Reims cedex, France.
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MeSH Terms
Adrenergic Agonists / pharmacology,  therapeutic use
Dose-Response Relationship, Drug
Ischemic Preconditioning, Myocardial / methods*
Myocardial Reperfusion Injury / drug therapy,  physiopathology*,  prevention & control*
Rats, Wistar
Receptors, Adrenergic, beta-1 / agonists,  physiology*
Receptors, Adrenergic, beta-2 / agonists,  physiology*
Reg. No./Substance:
0/Adrenergic Agonists; 0/Receptors, Adrenergic, beta-1; 0/Receptors, Adrenergic, beta-2

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