Document Detail

Role of the baroreceptor reflex in the early phases after removing the renal artery constriction in conscious renal hypertensive rats.
MedLine Citation:
PMID:  616174     Owner:  NLM     Status:  MEDLINE    
Hemodynamic studies in unanesthetized rats with chronic one-kidney-Goldblatt hypertension showed a 25% increase in cardiac output and a 42% increase in peripheral resistance. Removal of renal artery constriction under either anesthesia and minor surgical trauma produced an immediate 20% drop in arterial pressure. At the end of the 6 observation period the pressure dropped 30% but still remained at a moderate hypertensive level. The hemodynamic measurement at that time suggested that the pressure drop was the result of a decrease in cardiac output. However, the data obtained 1 hour after removal of the constriction suggested that a vasodilating mechanism may also contribute to pressure normalization in the early phase of reversal of renal hypertension. In the sham-operated hypertensive rats the pressure remained unchanged, while the cardiac output dropped due to compensation by a proportional increase in peripheral resistance. In contrast, in the unclipped animals the same drop in cardiac output produced an equivalent fall in pressure because no change in peripheral resistance occurred. This was not due to an insufficiency of the baroreceptor reflex since bilateral splanchnicectomy performed at that time produced a striking hypotensive response, indicating an overactivity of the sympathetic system possibly due to the baroreceptor still reset to operate at a hypertensive level.
E M Krieger; J R Brenes; H C Salgado; C J Assan; M C Salgado
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica latino americana     Volume:  27     ISSN:  0001-6764     ISO Abbreviation:  Acta Physiol Lat Am     Publication Date:  1977  
Date Detail:
Created Date:  1978-10-25     Completed Date:  1978-10-25     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0060610     Medline TA:  Acta Physiol Lat Am     Country:  ARGENTINA    
Other Details:
Languages:  eng     Pagination:  49-58     Citation Subset:  IM    
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MeSH Terms
Hypertension, Renal / physiopathology*,  surgery
Pressoreceptors / physiology*
Renal Artery / physiopathology*,  surgery
Splanchnic Nerves / surgery

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