Document Detail


Role of bacterial superantigens in atopic dermatitis : implications for future therapeutic strategies.
MedLine Citation:
PMID:  17007538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of staphylococcal superantigens in the pathophysiology of atopic dermatitis (AD) has been the focus of intense interest during the past decade. Although the increased prevalence of Staphylococcus aureus and its bacterial toxins in AD skin is well established, exploitation of the known mechanisms of superantigens in this disease for the development of novel therapies remains an active area of research. With the emergence of multi-drug resistant S. aureus, the need for a better understanding of the pathophysiology of bacterial superantigens in AD has become increasingly important. This review examines the mechanisms of S. aureus colonization and infection, of which the most important are defective skin barrier function, increased S. aureus adherence, and the decreased innate immune responses found in AD skin. The contribution of superantigens to the pathophysiology of AD is then discussed. Important immunologic mechanisms in this context include the role of superantigens in promoting T helper-2 skin inflammation, IgE production, T-regulatory cell subversion, expansion and migration of skin-homing T cells, and IgE anti-superantigen production. Lastly, these findings are discussed with reference to current therapeutic approaches, of which the most important include anti-inflammatory and antimicrobial medications, and future strategies, which are expected to consist of immune-modulators and synthetic antibacterials.
Authors:
Ivan D Cardona; Sang Hyun Cho; Donald Y M Leung
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  American journal of clinical dermatology     Volume:  7     ISSN:  1175-0561     ISO Abbreviation:  Am J Clin Dermatol     Publication Date:  2006  
Date Detail:
Created Date:  2006-09-29     Completed Date:  2007-01-18     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100895290     Medline TA:  Am J Clin Dermatol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  273-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / therapeutic use
Anti-Inflammatory Agents / therapeutic use
Combined Modality Therapy
Dermatitis, Atopic / immunology,  microbiology*
Humans
Lymphocyte Activation / immunology
Staphylococcal Infections / immunology*,  microbiology,  therapy
Staphylococcus aureus / immunology*
Superantigens / immunology*
Grant Support
ID/Acronym/Agency:
3M01 RR00051/RR/NCRR NIH HHS; AR41256/AR/NIAMS NIH HHS; HL-36577/HL/NHLBI NIH HHS; HL37260/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents; 0/Superantigens

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