Document Detail


Role of bacterial colonization in neonatal necrotizing enterocolitis and its prevention.
MedLine Citation:
PMID:  9926507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in premature infants. A major component of the pathophysiology of NEC is the nature of the interaction of bacteria with the premature gut. Intestine microflora are important to the host in resistance to bacterial infections. Diet and environmental conditions can influence this ecosystem. A breast-fed full-term infant has a preferred intestine microbiota in which bifidobacteria predominate over the potentially harmful bacteria, whereas in formula-fed infants coliforms, enterococci and bacteroides predominate. The pattern of bacterial colonization in the premature neonate gut is quite different from that in the gut of the healthy full-term infant. Those infants requiring intensive care acquire intestinal organisms slowly, and the establishment of bifidobacterial flora is retarded. A delayed bacterial colonization of the gut with a limited number of bacterial species tends to be virulent. Bacterial overgrowth is one of major factors promoting bacterial translocation. The aberrant colonization of the premature infant may contribute to the development of NEC. Breast feeding protects infants against NEC. Oligosaccharides and glycoconjugates, natural components in human milk, may prevent intestinal attachment of enteropathogens by acting as receptor homologues. Probiotics and prebiotics modulate the composition of human intestine microflora to the benefit of the host. The beneficial effects may result in the suppression of colonization of harmful microoganisms and/or the stimulation of bifidobacterial growth. In the future, control and manipulation of bacterial colonization in the neonate gut may be a new approach to the prevention and treatment of bacterial intestinal disease of various etiologies.
Authors:
D Dai; W A Walker
Related Documents :
15300557 - Further evidence for an ischemic origin of perforation of the appendix in the neonatal ...
22025567 - Visual cortical function in very low birth weight infants without retinal or cerebral p...
8548207 - Necrotizing enterocolitis.
18687047 - Enterobacter sakazakii: an emerging pathogen in infants and neonates.
9279157 - Bone marrow trephine biopsy in infants. european neuroblastoma study group.
435517 - Spectral characterization of the neuronal pigments of aplysia juliana.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Zhonghua Minguo xiao er ke yi xue hui za zhi [Journal]. Zhonghua Minguo xiao er ke yi xue hui     Volume:  39     ISSN:  0001-6578     ISO Abbreviation:  Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-02-18     Completed Date:  1999-02-18     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  16210470R     Medline TA:  Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  357-65     Citation Subset:  IM    
Affiliation:
Shanghai Institute for Pediatric Research, Shanghai Second Medical University, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bacteria / growth & development
Breast Feeding
Enterocolitis, Necrotizing / microbiology*,  prevention & control
Humans
Infant, Newborn
Intestines / microbiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reducing economic disparity to achieve better health: modelling the effect of adjustments to income ...
Next Document:  Hepatocellular carcinoma in children.