Document Detail

Role of autologous lymphocyte cytotoxicity in colonic neoplasia.
MedLine Citation:
PMID:  6976915     Owner:  NLM     Status:  MEDLINE    
The T-lymphocyte mediated killing of autologous carcinoma colon cells was investigated. There was no change in the incidence of activity with advanced disease, age, or nutritional status of the patient and no difference could be demonstrated in lymphocytes extracted from blood, draining lymph nodes, or the tumour itself. Nevertheless. T-lymphocyte activity did appear to be specific for the patients's own tumour, as it was rarely observed with allogeneic tumours. There was also no correlation with lymphocyte natural killer activity. The in vitro studies demonstrated patient specific T-lymphocyte activity in 23 of 47 patients with carcinoma of the colon, but the results do not correlate with clinical and pathological findings.
P Gallagher; B M Vose; M Moore; P F Schofield
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gut     Volume:  23     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Line
Colonic Neoplasms / immunology*,  pathology
Cytotoxicity, Immunologic*
Lymph Nodes / immunology
Middle Aged
T-Lymphocytes / immunology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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