| Role of attenuation correction for fluorine-18 fluorodeoxyglucose positron emission tomography in the primary staging of malignant lymphoma. | |
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MedLine Citation:
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PMID: 9933659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) has been shown to improve the diagnostic accuracy in the staging of malignant lymphomas, based on the metabolic signal of the lesions. This study was undertaken to determine the effect of attenuation correction in the detection of nodal and extranodal lesions in the primary staging of malignant lymphomas. Fifty-one untreated patients with either non-Hodgkin lymphoma (NHL, n=29) or Hodgkin's disease (n=22) were retrospectively evaluated. Static FDG-PET imaging of the trunk was performed following administration of 250-350 MBq FDG. Attenuation correction was performed in all patients. Images were reconstructed iteratively with or without transmission scans. Image evaluation was performed independently by two observers, who each examined one set of images (i.e. attenuation-corrected or uncorrected). The final decision as to whether results were discordant was reached by consensus of both observers. Out of 593 evaluated lymph node regions, 187 regions of increased FDG uptake were identified by both techniques. Differences between the readers concerned mainly the anatomical assignment of lesions (n=33) or the status (benign/malignant) of individual lesions (n=24). However, direct comparison of the two sets of images demonstrated very similar lesion contrast on attenuation-corrected and non-attenuation-corrected images. Real differences could be determined only in five regions (neck, 1; mediastinum, 1; upper abdomen, 3). Thirty-seven extranodal lesions (including lung, liver, spleen, bone marrow and soft tissue) were detected by both techniques without significant differences. It is concluded that in this study, attenuation correction did not improve the diagnostic accuracy of FDG-PET in the detection of lymph node or organ involvement during the primary staging of malignant lymphomas. Of more importance seemed to be the experience of the reader regarding the classification of a lesion's status the anatomical assignment, knowledge of physiological uptake and artefacts, and systematic and skillful examination of all regions scanned. |
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Authors:
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J Kotzerke; A Guhlmann; F Moog; N Frickhofen; S N Reske |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of nuclear medicine Volume: 26 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-02-25 Completed Date: 1999-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY |
Other Details:
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Languages: eng Pagination: 31-8 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, University of Ulm, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Female Fluorine Radioisotopes / diagnostic use* Fluorodeoxyglucose F18 / diagnostic use* Hodgkin Disease / pathology, radionuclide imaging* Humans Image Processing, Computer-Assisted Lymphoma, Non-Hodgkin / pathology, radionuclide imaging* Male Middle Aged Neoplasm Staging Radiopharmaceuticals / diagnostic use* Tomography, Emission-Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Fluorine Radioisotopes; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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