Document Detail

Role of atrial natriuretic peptide in pulmonary permeability and vasoregulation in ovine sepsis.
MedLine Citation:
PMID:  15599156     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Atrial natriuretic peptide is regarded as an important regulator of pulmonary vasomotor tone and permeability. This study investigated the role of atrial natriuretic peptide in sepsis-associated pulmonary pathophysiology. DESIGN: Prospective experimental investigation. SETTING: Laboratory at a university hospital. SUBJECTS: Twelve awake, chronically instrumented sheep. INTERVENTIONS: The sheep were instrumented with lung lymph fistulas and received a continuous infusion with live Pseudomonas aeruginosa for 48 hrs. After 40 hrs, the atrial natriuretic peptide-receptor antagonist HS-142-1 was continuously infused in the HS-124-1 group (3 mg/kg/hr, n = 6) for 8 hrs, whereas the control group received the carrier (n = 6). MEASUREMENTS AND MAIN RESULTS: Lung lymph flow was markedly elevated in response to sepsis after 40 hrs in both groups. Atrial natriuretic peptide-receptor blockade further increased lymph flows by 41 +/- 17% (41 hrs) up to 64 +/- 20% (44 hrs, p < .05) in the presence of normal permeability to protein. Although mean pulmonary artery pressure increased (p < .05 vs. 40 hrs), capillary pressure remained unaffected. Despite identical fluid balances in both groups, cardiovascular filling variables significantly increased in the HS-142-1 group. This was associated with increasing cardiac index and mean arterial pressure (p < .05 vs. 40 hrs). In the control group, all variables remained constant between 41 and 48 hrs. CONCLUSION: Blockade of atrial natriuretic peptide receptors increases pulmonary transvascular fluid flux independent of changes in permeability to protein in chronic ovine sepsis. Atrial natriuretic peptide may therefore play a protective role for the alveolar-capillary barrier during sepsis.
Henning D Stubbe; Daniel L Traber; Michael Booke; Lillian D Traber; Martin Westphal; Hugo Van Aken; Frank Hinder
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  32     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-15     Completed Date:  2005-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2491-5     Citation Subset:  AIM; IM    
Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Münster, Germany.
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MeSH Terms
Atrial Natriuretic Factor / analysis,  metabolism*
Disease Models, Animal
Lung / physiology*
Lymphatic System / drug effects,  physiology
Permeability / drug effects
Pseudomonas Infections / drug therapy*
Pulmonary Circulation / drug effects,  physiology
Pulmonary Edema / drug therapy*,  physiopathology*
Receptors, Atrial Natriuretic Factor / antagonists & inhibitors*
Reference Values
Risk Factors
Sensitivity and Specificity
Sepsis / drug therapy,  microbiology
Sheep, Domestic
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor; EC, Atrial Natriuretic Factor

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