Document Detail

Role of astrovirus in intussusception in Nigerian infants.
MedLine Citation:
PMID:  19052076     Owner:  NLM     Status:  MEDLINE    
Intussusception (IS) is a form of intestinal obstruction in which a segment of the bowel prolapses into a more distal segment. Viral infections, mostly adenovirus, enteroviruses, human herpesvirus and Epstein-Barr virus are reported in 20-50% of childhood cases of IS. Between January and July 2004, six stool specimens collected from infants 0- to 8-months old diagnosed and admitted for IS were investigated for the presence of rotavirus, astrovirus and adenovirus antigens. Astrovirus antigen was detected in three of the six stool specimens by enzyme immune assay (EIA) and confirmed in two specimens by reverse transcription-polymerase chain reaction (RT-PCR). Rotavirus, non-enteric adenovirus and astrovirus were detected by EIA, as mixed infections in a single specimen. The rotavirus strain revealed a SGI+II, mixed G1G2G8P[6] genotype and had no visible electrophoretic profile. A larger study is needed to determine the extent of involvement of astroviruses in IS in infants and the virus should be included in studies investigating the aetiology of IS.
M Aminu; E A Ameh; A Geyer; M D Esona; M B Taylor; A D Steele
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-03
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  55     ISSN:  1465-3664     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-05     Completed Date:  2009-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  England    
Other Details:
Languages:  eng     Pagination:  192-4     Citation Subset:  IM    
Department of Microbiology, Ahmadu Bello University, Zaria, Nigeria.
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MeSH Terms
Adenoviridae / genetics,  isolation & purification*
Astroviridae / genetics,  isolation & purification*
Astroviridae Infections / diagnosis,  epidemiology
DNA, Viral / genetics
Electrophoresis, Polyacrylamide Gel
Feces / virology*
Immunoenzyme Techniques
Infant, Newborn
Intussusception / diagnosis,  epidemiology,  virology*
Nigeria / epidemiology
RNA, Viral / analysis
Reverse Transcriptase Polymerase Chain Reaction
Rotavirus / genetics,  isolation & purification*
Reg. No./Substance:
0/DNA, Viral; 0/RNA, Viral

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