| Role of astrovirus in intussusception in Nigerian infants. | |
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MedLine Citation:
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PMID: 19052076 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intussusception (IS) is a form of intestinal obstruction in which a segment of the bowel prolapses into a more distal segment. Viral infections, mostly adenovirus, enteroviruses, human herpesvirus and Epstein-Barr virus are reported in 20-50% of childhood cases of IS. Between January and July 2004, six stool specimens collected from infants 0- to 8-months old diagnosed and admitted for IS were investigated for the presence of rotavirus, astrovirus and adenovirus antigens. Astrovirus antigen was detected in three of the six stool specimens by enzyme immune assay (EIA) and confirmed in two specimens by reverse transcription-polymerase chain reaction (RT-PCR). Rotavirus, non-enteric adenovirus and astrovirus were detected by EIA, as mixed infections in a single specimen. The rotavirus strain revealed a SGI+II, mixed G1G2G8P[6] genotype and had no visible electrophoretic profile. A larger study is needed to determine the extent of involvement of astroviruses in IS in infants and the virus should be included in studies investigating the aetiology of IS. |
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Authors:
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M Aminu; E A Ameh; A Geyer; M D Esona; M B Taylor; A D Steele |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-03 |
Journal Detail:
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Title: Journal of tropical pediatrics Volume: 55 ISSN: 1465-3664 ISO Abbreviation: J. Trop. Pediatr. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-05 Completed Date: 2009-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8010948 Medline TA: J Trop Pediatr Country: England |
Other Details:
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Languages: eng Pagination: 192-4 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Ahmadu Bello University, Zaria, Nigeria. maryamaminu@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae
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genetics,
isolation & purification* Astroviridae / genetics, isolation & purification* Astroviridae Infections / diagnosis, epidemiology DNA, Viral / genetics Electrophoresis, Polyacrylamide Gel Feces / virology* Female Genotype Humans Immunoenzyme Techniques Infant Infant, Newborn Intussusception / diagnosis, epidemiology, virology* Male Nigeria / epidemiology RNA, Viral / analysis Reverse Transcriptase Polymerase Chain Reaction Rotavirus / genetics, isolation & purification* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/RNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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